ArticleApplied and environmental microbiology2017
Novel Antibiotic Resistance Determinants from Agricultural Soil Exposed to Antibiotics Widely Used in Human Medicine and Animal Farming.
Article in Applied and environmental microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
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- Metagenomics for antimicrobial resistance: from resistome surveillance to mechanistic inference.Journal of bacteriology · 2026Review
- Environmental Fate, Soil Ecological Responses and Fruit Quality Impacts of Emerging Contaminants (Antibiotics) in Orchard Ecosystems: A Review.Molecules (Basel, Switzerland) · 2026Review
- Achieving Lasting Umbilical Cord Decontamination and Sustainable Stem Cell Sourcing by Combining Plasma-Functionalized Liquid and Ultrasound.Foods (Basel, Switzerland) · 2026Article
- Potential of the livestock industry environment as a reservoir for spreading antimicrobial resistance.Open veterinary journal · 2025Review
- How Gut Microbiome Perturbation Caused by Antibiotic Pre-Treatments Affected the Conjugative Transfer of Antimicrobial Resistance Genes.Microorganisms · 2024Article
- Bacterial dynamics of the plastisphere microbiome exposed to sub-lethal antibiotic pollution.Microbiome · 2024Article
- Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics.Nature communications · 2023Article
- ResFinderFG v2.0: a database of antibiotic resistance genes obtained by functional metagenomics.Nucleic acids research · 2023Article
- Multi-group Analysis of Compositions of Microbiomes with Covariate Adjustments and Repeated Measures.Research square · 2023Article
- Molecular Characterization of Bacterial Isolates from Soil Samples and Evaluation of their Antibacterial Potential against MDRS.Molecules (Basel, Switzerland) · 2022Article
- Mobility ofMicrobial genomics · 2021Article
- Accurate acid dissociation constant (pKJournal of molecular modeling · 2021Article
- Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.Chemical reviews · 2021Review
- Novel Soil-Derived Beta-Lactam, Chloramphenicol, Fosfomycin and Trimethoprim Resistance Genes Revealed by Functional Metagenomics.Antibiotics (Basel, Switzerland) · 2021Article
- Target protection as a key antibiotic resistance mechanism.Nature reviews. Microbiology · 2020Review
- Quantitative study on the fate of antibiotic emissions in China.Environmental geochemistry and health · 2020Review
- Discovery of a novel integron-borne aminoglycoside resistance gene present in clinical pathogens by screening environmental bacterial communities.Microbiome · 2020Article
- Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mobility of β-Lactam Resistance Under Bacterial Co-infection and Ampicillin Treatment in a Mouse Model.Frontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance has emerged globally as one of the biggest threats to human and animal health. Although the excessive use of antibiotics is recognized as accelerating the selection for resistance, there is a growing body of evidence suggesting that natural environments are "hot spots" for the development of both ancient and contemporary resistance mechanisms. Given that pharmaceuticals can be entrained onto agricultural land through anthropogenic activities, this could be a potential driver for the emergence and dissemination of resistance in soil bacteria. Using functional metagenomics, we interrogated the "resistome" of bacterial communities found in a collection of Canadian agricultural soil, some of which had been receiving antibiotics widely used in human medicine (macrolides) or food animal production (sulfamethazine, chlortetracycline, and tylosin) for up to 16 years. Of the 34 new antibiotic resistance genes (ARGs) recovered, the majority were predicted to encode (multi)drug efflux systems, while a few share little to no homology with established resistance determinants. We characterized several novel gene products, including putative enzymes that can confer high-level resistance against aminoglycosides, sulfonamides, and broad range of beta-lactams, with respect to their resistance mechanisms and clinical significance. By coupling high-resolution proteomics analysis with functional metagenomics, we discovered an unusual peptide, PPP
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