Evidence map›Paper›PMID 28625839›Full record

Trial reportInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2017

Surveillance of upper respiratory infections using a new multiplex PCR assay compared to conventional methods during the influenza season in Taiwan.

Shu-Chun Chiu, Yung-Cheng Lin, Hsiao-Chi Wang, Jen-Jen Hsu, Ting-Kai Yeh, Hsin-Fu Liu, Jih-Hui Lin

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018
    Pooled it
  2. Review
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  5. Review
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  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shu-Chun ChiuCenter of Diagnostics and Vaccine Development, Centers for Disease Control, Taiwan, Taipei 11561, Taiwan.
Yung-Cheng LinDepartment of Medical Research, Mackay Memorial Hospital, New Taipei City 25160, Taiwan.
Hsiao-Chi WangCenter of Diagnostics and Vaccine Development, Centers for Disease Control, Taiwan, Taipei 11561, Taiwan; National Influenza Center, Centers for Disease Control, Taipei 11561, Taiwan.
Jen-Jen HsuCenter of Diagnostics and Vaccine Development, Centers for Disease Control, Taiwan, Taipei 11561, Taiwan.
Ting-Kai YehCenter of Diagnostics and Vaccine Development, Centers for Disease Control, Taiwan, Taipei 11561, Taiwan.
Hsin-Fu LiuDepartment of Medical Research, Mackay Memorial Hospital, New Taipei City 25160, Taiwan; Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 20224, Taiwan; Department of Nursing, National Taipei University of Nursing and Health Sciences, Taipei 11219, Taiwan. Electronic address: hsinfu@ms1.mmh.org.tw.
Jih-Hui LinCenter of Diagnostics and Vaccine Development, Centers for Disease Control, Taiwan, Taipei 11561, Taiwan; National Influenza Center, Centers for Disease Control, Taipei 11561, Taiwan. Electronic address: jeffy320@cdc.gov.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo improve diagnosis as part of laboratory surveillance in Taiwan, influenza-like illness (ILI) surveillance was conducted using a new multiplex PCR assay (FilmArray) and the results compared to those of conventional methods The study was performed during the winter months.

methodsThroat swabs from patients with an ILI presenting to physicians in sentinel practices were collected during the 2016-2017 influenza season.

resultsA total of 52 samples tested positive by FilmArray Respiratory Panel. Forty percent were influenza A virus, and subtype H3N2 virus was the major epidemic strain. However, nearly 60% of ILI cases seen at sentinel sites were caused by non-influenza pathogens. The results of the FilmArray assay and cell culture were identical, and this assay was more sensitive than a rapid influenza diagnostic test. Genetic analyses revealed new influenza A H3N2 variants belonging to a novel subclade 3C.2a2.

conclusionsThe FilmArray assay facilitates urgent testing and laboratory surveillance for common viral and bacterial respiratory pathogens. This study demonstrated the use of a highly sensitive assay using clinical samples that is feasible for application worldwide. This may lead to an increased rate of diagnosis of viral infections and to improved patient outcomes, and in particular to a reduction in the overuse of antibiotics and antivirals.

Indexed as

Multiplex Polymerase Chain ReactionAdolescentAdultAgedCell LineChildChild, PreschoolFemaleHumansInfantInfant, NewbornInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMaleMiddle AgedRespiratory Tract InfectionsInfluenza virusMultiplex PCRTaiwanURI

Identifiers

PMID28625839
PMCPMC7110889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.