ArticleStructure (London, England : 1993)2017
Structural and Functional Trends in Dehydrating Bimodules from trans-Acyltransferase Polyketide Synthases.
Article in Structure (London, England : 1993), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl-Substituted, α-Oxidized γ-Amino Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins.Science (New York, N.Y.) · 2024Article
- Dehydroamino acid residues in bioactive natural products.Natural product reports · 2024Review
- Giant polyketide synthase enzymes biosynthesize a giant marine polyether biotoxin.bioRxiv : the preprint server for biology · 2024Article
- Diene incorporation by a dehydratase domain variant in modular polyketide synthases.Nature chemical biology · 2022Article
- Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites.Beilstein journal of organic chemistry · 2022Article
- Molecular basis for acyl carrier protein-ketoreductase interaction inChemical science · 2021Article
- The Mechanism of Dehydrating Bimodules in trans-Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective Hangtaimycin.Angewandte Chemie (International ed. in English) · 2021Article
- Activation of silent biosynthetic gene clusters using transcription factor decoys.Nature chemical biology · 2019Article
- Structural and Functional Studies of a gem-Dimethylating Methyltransferase from a trans-Acyltransferase Assembly Line.ACS chemical biology · 2018Article
- pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism.Organic & biomolecular chemistry · 2018Article
- The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.Proteins · 2018Article
- Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.ACS chemical biology · 2018Article
- Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases.Nature chemical biology · 2018Article
- Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis.PloS one · 2018Article
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7 authors at 1 institution in 1 country.
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Abstract
In an effort to uncover the structural motifs and biosynthetic logic of the relatively uncharacterized trans-acyltransferase polyketide synthases, we have begun the dissection of the enigmatic dehydrating bimodules common in these enzymatic assembly lines. We report the 1.98 Å resolution structure of a ketoreductase (KR) from the first half of a type A dehydrating bimodule and the 2.22 Å resolution structure of a dehydratase (DH) from the second half of a type B dehydrating bimodule. The KR, from the third module of the bacillaene synthase, and the DH, from the tenth module of the difficidin synthase, possess features not observed in structurally characterized homologs. The DH architecture provides clues for how it catalyzes a unique double dehydration. Correlations between the chemistries proposed for dehydrating bimodules and bioinformatic analysis indicate that type A dehydrating bimodules generally produce an α/β-cis alkene moiety, while type B dehydrating bimodules generally produce an α/β-trans, γ/δ-cis diene moiety.
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