ArticleCurrent biology : CB2017
Probabilistic Invasion Underlies Natural Gut Microbiome Stability.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 1 of them a synthesis that pooled it.
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Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis suggests the microbiome responds to Evolve and Resequence experiments in Drosophila melanogaster.BMC microbiology · 2021Pooled it
- Microbiome-mediated resilience and cross-generational consequences in male Drosophila exposed to combined environmental stressors.Proceedings. Biological sciences · 2026Article
- The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome.eLife · 2026Article
- Article
- Stochastic colonization and host-to-host transmission shape gut bacterial variability.bioRxiv : the preprint server for biology · 2026Article
- Microbiota-Based Interventions Differentially Rescue Gut and Social Behavior Phenotypes in <italic>Drosophila</italic> with Kdm5 Deficiency.Developmental neuroscience · 2026Article
- Modulating microbial intake helps to maintain the gut microbiome diversity.Communications biology · 2026Article
- Article
- Host-Associated Bacterial Community Changes After Laboratory Introduction Vary With Wolbachia Presence.Environmental microbiology · 2026Article
- Cluster dispersal shapes microbial diversity during community assembly.PLoS computational biology · 2026Article
- Microbiota-Based Interventions Differentially Rescue Gut and Social Behavior Phenotypes in a Drosophila Autism-like Model.bioRxiv : the preprint server for biology · 2026Article
- Gut microbial metabolites link dietary history to appetite regulation.Journal of neurogenetics · 2025Article
- Environment and diet shape the geography-specificApplied and environmental microbiology · 2025Article
- Is it time to assignApplied and environmental microbiology · 2025Article
- Microbiome composition and co-occurrence dynamics in wildMicrobiology spectrum · 2025Article
- Structure, function, and quantitative biology of the Drosophila gut microbiome.Current opinion in microbiology · 2025Review
- Effects of species and sex on the gut microbiome of four laboratory-reared fruit fly lines (Diptera: Tephritidae) using full-length 16S rRNA PacBio Kinnex sequencing.BMC microbiology · 2025Article
- Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing.Microbiology spectrum · 2025Article
- Gut microbe-derived lactic acid optimizes host energy metabolism during starvation.bioRxiv : the preprint server for biology · 2025Article
- Review
58 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
Species compositions of gut microbiomes impact host health [1-3], but the processes determining these compositions are largely unknown. An unexplained observation is that gut species composition varies widely between individuals but is largely stable over time within individuals [4, 5]. Stochastic factors during establishment may drive these alternative stable states (colonized versus non-colonized) [6, 7], which can influence susceptibility to pathogens, such as Clostridium difficile. Here we sought to quantify and model the dose response, dynamics, and stability of bacterial colonization in the fruit fly (Drosophila melanogaster) gut. Our precise, high-throughput technique revealed stable between-host variation in colonization when individual germ-free flies were fed their own natural commensals (including the probiotic Lactobacillus plantarum). Some flies were colonized while others remained germ-free even at extremely high bacterial doses. Thus, alternative stable states of colonization exist even in this low-complexity model of host-microbe interactions. These alternative states are driven by a fundamental asymmetry between the inoculum population and the stably colonized population that is mediated by spatial localization and a population bottleneck, which makes stochastic effects important by lowering the effective population size. Prior colonization with other bacteria reduced the chances of subsequent colonization, thus increasing the stability of higher-diversity guts. Therefore, stable gut diversity may be driven by inherently stochastic processes, which has important implications for combatting infectious diseases and for stably establishing probiotics in the gut.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.