ArticleNeuron2017
A Corticothalamic Circuit for Dynamic Switching between Feature Detection and Discrimination.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
What it found
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Who cites it
121 citing papers in PubMed, 211 citations in OpenAlex.
- Article
- Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury.Science advances · 2026Article
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments.bioRxiv : the preprint server for biology · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Layer 5 and 6b extratelencephalic neurons encode distinct sound features in auditory cortex.bioRxiv : the preprint server for biology · 2026Article
- Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Thalamic reticular neurons provide cell type-specific modulation of sound processing in the auditory thalamus.PLoS biology · 2026Article
- Timing and Convergence of Ensemble Activity Govern Auditory Thalamocortical Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex.Cell reports · 2026Article
- Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Synaptic Properties of Layer 6 Auditory Corticothalamic Inputs in Normal Hearing and Noise-Induced Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- The neural basis for uncertainty processing in hierarchical decision making.Nature communications · 2025Article
- Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex.Cell reports · 2025Article
- Cell type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer cortical neurons after noise trauma.Science advances · 2025Article
- Primary auditory cortex is necessary for the acquisition and expression of categorical behavior.Current biology : CB · 2025Article
- Actions of the antiseizure drug carbamazepine in the thalamic reticular nucleus: Potential mechanism of aggravating absence seizures.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Sensory processing must be sensitive enough to encode faint signals near the noise floor but selective enough to differentiate between similar stimuli. Here we describe a layer 6 corticothalamic (L6 CT) circuit in the mouse auditory forebrain that alternately biases sound processing toward hypersensitivity and improved behavioral sound detection or dampened excitability and enhanced sound discrimination. Optogenetic activation of L6 CT neurons could increase or decrease the gain and tuning precision in the thalamus and all layers of the cortical column, depending on the timing between L6 CT activation and sensory stimulation. The direction of neural and perceptual modulation - enhanced detection at the expense of discrimination or vice versa - arose from the interaction of L6 CT neurons and subnetworks of fast-spiking inhibitory neurons that reset the phase of low-frequency cortical rhythms. These findings suggest that L6 CT neurons contribute to the resolution of the competing demands of detection and discrimination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.