ArticleNeuron2017
Motor Cortical Visuomotor Feedback Activity Is Initially Isolated from Downstream Targets in Output-Null Neural State Space Dimensions.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 124 citations in OpenAlex.
- Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.Journal of neural engineering · 2020Trial
- Duration-modulated neural population dynamics in humans during BMI controls.Communications biology · 2026Article
- Flexible integration of corollary discharge and sensory feedback signals in somatosensory cortex.bioRxiv : the preprint server for biology · 2026Article
- Data-derived agents reveal dynamical reservoirs in mouse cortex for adaptive behavior.bioRxiv : the preprint server for biology · 2026Article
- Facial gestures are enacted through a cortical hierarchy of dynamic and stable codes.Science (New York, N.Y.) · 2026Article
- Brain-wide analysis reveals movement encoding structured across and within brain areas.Nature neuroscience · 2026Article
- Striatal ensembles specify and control granular forelimb actions.bioRxiv : the preprint server for biology · 2025Article
- Motor Cortical Output Integrates Distorted Proprioceptive Feedback.bioRxiv : the preprint server for biology · 2025Article
- A posture subspace in the primary motor cortex.Neuron · 2025Article
- A transformation from vision to imagery in the human brain.bioRxiv : the preprint server for biology · 2025Article
- An instantaneous voice-synthesis neuroprosthesis.Nature · 2025Article
- Neural geometry from mixed sensorimotor selectivity for predictive sensorimotor control.eLife · 2025Article
- Visual target and task-critical feedback uncertainty impair different stages of reach planning in motor cortex.Nature communications · 2025Article
- A neural implementation model of feedback-based motor learning.Nature communications · 2025Article
- A theory of brain-computer interface learning via low-dimensional control.bioRxiv : the preprint server for biology · 2025Article
- When preparation pays off.eLife · 2024Article
- An instantaneous voice synthesis neuroprosthesis.bioRxiv : the preprint server for biology · 2024Article
- An output-null signature of inertial load in motor cortex.Nature communications · 2024Article
- Article
- Preparatory activity and the expansive null-space.Nature reviews. Neuroscience · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Neural circuits must transform new inputs into outputs without prematurely affecting downstream circuits while still maintaining other ongoing communication with these targets. We investigated how this isolation is achieved in the motor cortex when macaques received visual feedback signaling a movement perturbation. To overcome limitations in estimating the mapping from cortex to arm movements, we also conducted brain-machine interface (BMI) experiments where we could definitively identify neural firing patterns as output-null or output-potent. This revealed that perturbation-evoked responses were initially restricted to output-null patterns that cancelled out at the neural population code readout and only later entered output-potent neural dimensions. This mechanism was facilitated by the circuit's large null space and its ability to strongly modulate output-potent dimensions when generating corrective movements. These results show that the nervous system can temporarily isolate portions of a circuit's activity from its downstream targets by restricting this activity to the circuit's output-null neural dimensions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.