Evidence map›Paper›PMID 28625080›Full record

ArticleMolecular imaging2017

In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.

Benjamin L Franc, Sam Goth, John MacKenzie, Xiaojuan Li, Joseph Blecha, Tina Lam, Salma Jivan, Randall A Hawkins, Henry VanBrocklin

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03684655 phase2recruitingnot on this mapstarted 2018, after this paper: background citation

Imaging Immune Activation in HIV Infection

TypeinterventionalSponsorCellSight Technologies, Inc.Ran2018 to 2025Enrolled30ConditionsHIV InfectionsArms[18F]F-AraG (2'-deoxy-2'-fluoro-9-β-D-arabinofuranosylguanine)
NCT04052412 phase1unknown statusnot on this mapstarted 2019, after this paper: background citation

Biodistribution and Kinetics of 18F-AraG in Non-Small Cell Lung Cancer Patients Before and After Immunotherapy With and Without Radiation

TypeinterventionalSponsorUniversity of TennesseeRan2019 to 2023Enrolled2ConditionsNon-small Cell Lung CancerArms18F-AraG
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  4. Review
  5. A Feasibility Study of [Molecular imaging and biology · 2024
    Article
  6. Article
  7. Noninvasive Imaging OX40Molecular imaging and biology · 2023
    Article
  8. An improved radiosynthesis of [Journal of labelled compounds & radiopharmaceuticals · 2022
    Article
  9. Simplified and accessible [Journal of labelled compounds & radiopharmaceuticals · 2022
    Article
  10. Visualizing T-Cell Responses: The T-Cell PET Imaging Toolbox.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  11. Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  12. Review
  13. Article
  14. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Imaging activated T cells predicts response to cancer vaccines.The Journal of clinical investigation · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Benjamin L Franc1 Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, USA.
Sam Goth2 Cellsight Technologies, Inc, San Francisco, CA, USA.
John MacKenzie1 Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, USA.
Xiaojuan Li1 Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, USA.
Joseph Blecha1 Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, USA.
Tina Lam2 Cellsight Technologies, Inc, San Francisco, CA, USA.
Salma Jivan1 Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, USA.
Randall A Hawkins1 Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, USA.
Henry VanBrocklin1 Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USCellSight Technologies (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvolving immune-mediated therapeutic strategies for rheumatoid arthritis (RA) may benefit from an improved understanding of the complex role that T-cell activation plays in RA. This study assessed the potential of fluorine-18-labeled 9-β-d-arabinofuranosylguanine ([

methodsUsing positron emission tomography-computed tomography imaging, uptake of [

resultsDifferential uptake of [

conclusion[

Indexed as

AnimalsArthritisB-LymphocytesDisease Models, AnimalFlow CytometryMiceMice, Inbred BALB CMolecular ImagingPositron-Emission TomographyT-Lymphocytesanimal models of diseasemolecular imaging of inflammation

Identifiers

PMID28625080
PMCPMC5480631
OpenAlexW2630273891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.