Evidence map›Paper›PMID 28625011›Full record

ArticleCytotechnology2018

Liver epithelioid progenitor cells derived from fetal Luxi bovine alleviate liver fibrosis.

Kunfu Wang, Hao Liu, Jinjuan Yang, Caiyun Ma, Zebiao Zhang, Dong Zheng, Weijun Guan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kunfu WangCollege of Wildlife Resources, Northeast Forestry University, Harbin, 150040, China.
Hao LiuInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Jinjuan YangInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Caiyun MaInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Zebiao ZhangInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Dong ZhengCollege of Wildlife Resources, Northeast Forestry University, Harbin, 150040, China. zhengdong89@163.com.
Weijun GuanInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. wjguan86@163.com.
Chinese Academy of Agricultural Sciences · CNNortheast Forestry University · CN

Funding

Agricultural Science and Technology Innovation Program cxgc-ias-01National Natural Science Foundation of China 31472099; 31672404the project National Infrastructure of Animal Germplasm Resources 2016
6 · The paper itself

Abstract

Liver epithelioid progenitor cells (LEPCs) have important roles in liver therapy because of their hepatic differentiation potency in vitro and in vivo. Despite many researches on humans, mice, and rats, equivalent progenitor cells derived from bovine are relatively rare. The purpose of our current study is to characterize bovine LEPCs, and research on the cure potency of this heteroplastic progenitor cells on mice liver fibrosis. We have used collagenase IV digesting and differential adhesion method to isolate slabstone shape, EpCAM, LGR5, NCAM1 and SOX9 positive progenitor cells from fetal Luxi bovine liver. When cultured in hepatic differentiation media containing 20 ng/ml Oncostatin M, LEPCs can differentiate into hepatocytes in vitro. After 4 weeks of intravenous tail vein injection into CCl

Indexed as

Hepatocyte differentiationHeterogeneous cell transplantationLiver epithelioid progenitor cellsLiver fibrosisStem cells therapy

Identifiers

PMID28625011
PMCPMC5809641
OpenAlexW2626719575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.