ArticleBiogerontology2017
Towards ageing well: Use it or lose it: Exercise, epigenetics and cognition.
Article in Biogerontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Vitamin DJournal of cachexia, sarcopenia and muscle · 2021Trial
- Vigorous Physical Activity Mitigates Susceptibility to Obesity Associated with Risk Genotypes ofEpigenomes · 2026Article
- Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity.Aging medicine (Milton (N.S.W)) · 2026Review
- Social support and anxiety, a moderated mediating model.Scientific reports · 2025Article
- Healthy Aging in a Religious Congregation: A Study About Lifestyles and Health Behaviors Among Consecrated Women in Poland and Other Countries.Healthcare (Basel, Switzerland) · 2025Article
- Engagement in Ageless Gym Programs Among Older Adults in Rural Communities: A Retrospective Study on Relationships With Age, Health Conditions, and Proximity to Health Facilities.Journal of aging research · 2025Article
- Recommendations for Healthy Lifestyle for Cancer Prevention and Healthy Aging.Journal of cancer prevention · 2024Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration inScience advances · 2023Article
- A perspective on the role of physiological stresses in cancer, diabetes and cognitive disease as environmental diseases.Frontiers in molecular biosciences · 2023Article
- Exercise and microbiome: From big data to therapy.Computational and structural biotechnology journal · 2023Review
- Genomic and Epigenomic Evaluation of Electrically Induced Exercise in People With Spinal Cord Injury: Application to Precision Rehabilitation.Physical therapy · 2022Article
- Grandchild Caregiving and Cognitive Health Among Grandparents in Rural South Africa.Journal of aging and health · 2021Article
- Review
- Skeletal muscle-specific calpastatin overexpression mitigates muscle weakness in aging and extends life span.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Chronic obstructive pulmonary disease does not impair responses to resistance training.Journal of translational medicine · 2021Article
- Physical Exercise as a Resilience Factor to Mitigate COVID-Related Allostatic Overload.Psychotherapy and psychosomatics · 2021Article
- Winter of our contentment: Examining risk, pleasure, and emplacement in later-life physical activity.Journal of aging studies · 2020Article
- Effects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats.Metabolites · 2020Article
- Well-aging: A new strategy for skin homeostasis under multi-stressed conditions.Journal of cosmetic dermatology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More and more people are living into the 90s or becoming centenarians. But, the gift of increased 'age span' seldom equates with an improved 'health-span'. Governments across the world are expressing concern about the epidemic of chronic disease, and have responded by initiating policies that make prevention, reduction and treatment of chronic disease, a public health priority. But understanding, how to age long and well, with the avoidance of chronic disease and later life complex disease morbidity is challenging. While inherited genes have an undoubted role to play in the chance of maintaining good health or conversely a predilection to developing disease and chronic ill health, there is increasing evidence that behavioural and environmental life-style choices may contribute up to 50% of the variability of human lifespan. Physical exercise is readily available to everyone, and is a simple cheap and effective form of life-style intervention. Exercise appears to help maintain good health and to reduce the risk of developing chronic disease and ill health. Evidence suggests that physical activity improves well-being across many health domains through out life, continues to offer important health benefits in older age groups and tracks with a 'healthy ageing' profile. Although many of the molecular pathways remain to be fully identified, here we discuss how physical activity and exercise is understood to produce changes in the human epigenome, which have the potential to enhance cognitive and psychological health, improve muscular fitness, and lead to better ageing with improved quality of life in older age.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.