ReviewClinical rheumatology2017
Familial Mediterranean fever, review of the literature.
Review in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05488561 (Clinical and Molecular Evaluation of Childern With Familial Meditterranean Fever and Their Siblings), which is not on this map. Cited by 87 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical and Molecular Evaluation of Childern With Familial Meditterranean Fever and Their Siblings
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 209 citations in OpenAlex.
- Effectiveness and Safety of JAK Inhibitors in Autoinflammatory Diseases: A Systematic Review.Frontiers in medicine · 2022Pooled it
- Long-term efficacy and safety of canakinumab in patients with colchicine-resistant familial Mediterranean fever: results from the randomised phase III CLUSTER trial.Annals of the rheumatic diseases · 2020Trial
- Clinical and genetic characteristics of adult patients with familial Mediterranean fever at a German tertiary referral centre.BMC rheumatology · 2026Article
- Cardiovascular Risk and Bone Mineral Density in Children with Familial Mediterranean Fever: The Role of Disease Severity and Genetic Mutations.International journal of molecular sciences · 2026Article
- Recurrent Isolated Sixth Cranial Nerve Palsy Despite Normal Neuroimaging in Familial Mediterranean Fever.International journal of rheumatic diseases · 2026Article
- Exploring the Role of Vitamin D in Familial Mediterranean Fever: Pathogenesis, Triggers, and Immune Modulation.Medical sciences (Basel, Switzerland) · 2026Review
- Amyloidosis secondary to familial Mediterranean fever: machine learning-based prediction models.Rheumatology (Oxford, England) · 2026Article
- Colchicine discontinuation in familial Mediterranean fever: short-term outcomes by pre-discontinuation attack frequency.Clinical rheumatology · 2026Article
- Familial Mediterranean Fever: A Comprehensive Review of Pathogenesis, Genetics, and Epigenetic Regulation.Balkan medical journal · 2026Review
- Identification of pathogenicJournal of rheumatic diseases · 2025Article
- Obstetric and neonatal outcomes in pregnancies with familial mediterranean fever: a comparative study.Rheumatology international · 2025Article
- Efficacy and Safety of Anakinra in Colchicine-Resistant or -Intolerant Familial Mediterranean Fever: A Single-Center Real-Life Experience.Medicina (Kaunas, Lithuania) · 2025Article
- Familial Mediterranean fever with sigmoid colon stricture.Clinical journal of gastroenterology · 2025Article
- The Role ofInternational journal of molecular sciences · 2025Article
- Familial Mediterranean Fever Intertwined With a Diagnosis of Crohn's Disease: A Case Report.Cureus · 2025Article
- Characteristics of Siblings with Familial Mediterranean Fever: A Single-Center Experience.Turkish archives of pediatrics · 2025Article
- A Unique Complex Variation Profile in a Patient with Familial Mediterranean Fever (FMF): Triple Homozygous E148Q-P369S-R408Q - "Case Report".The application of clinical genetics · 2025Article
- Familial Mediterranean Fever as a Cause of Recurrent Pleurisy in a Child With Crohn's Disease: A Case Report.Case reports in pulmonology · 2025Article
- Vasculitis as an indicator of disease severity in familial Mediterranean fever.Frontiers in immunology · 2025Article
- The efficacy of a single-dose anakinra injection during disease attack in pediatric familial Mediterranean fever.Rheumatology international · 2024Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Familial Mediterranean fever (FMF) is the most common monogenic periodic fever syndrome and characterized by recurrent episodes of fever, serositis, arthritis, dermal manifestations, and long-term renal complications. The MEFV gene was described in 1997 as the gene responsible for FMF and is inherited in autosomal recessive manner. It encodes mutated protein pyrin, an important player in the innate immune system and the component of inflammasome which leads to exaggerated inflammatory response through uncontrolled production of interleukin-1. The recent progress in molecular genetics and understanding of pathogenesis showed a more complicated picture of FMF inheritance, penetrance, and pathogenesis. The pathogenesis is not completely understood although the gene responsible for FMF has been identified. Whether the pyrin mutation effect in FMF is due to a loss of function or a gain of function is still controversial. The diagnosis is mainly clinical and the genetic testing is indicated to support it. Colchicine remains the mainstay of treatment of FMF since 1972. It decreases the attacks, improves quality of life, and prevents amyloidosis. The recent advances in genetic testing and molecular studies has led to the development of new therapies of interleukin-1 inhibitors; anakinra, canakinumab, and rilonacept.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.