Evidence map›Paper›PMID 28624863›Full record

ArticleInternational journal of clinical oncology2017

Matched-pair analysis of patients with advanced hypopharyngeal cancer: surgery versus concomitant chemoradiotherapy.

Shigemichi Iwae, Masato Fujii, Ryuichi Hayashi, Yasuhisa Hasegawa, Takashi Fujii, Kenji Okami, Akihiro Homma, Tetsuro Onitsuka, Takakuni Kato, Takenori Ogawa and 11 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of clinical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Upfront Surgery Versus Upfront Concurrent Chemoradiotherapy as Primary Modality in Hypopharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Pooled it
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  18. Thyroid Gland Flap for Minimally Invasive Reconstructive Head and Neck Surgery.Plastic and reconstructive surgery. Global open · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 1 country.

Shigemichi IwaeDepartment of Head and Neck Surgery, Hyogo Cancer Center, 13-70 Kitaoji, Akashi, Hyogo, 673-8558, Japan. s.iwae@hp.pref.hyogo.jp.ORCID http://orcid.org/0000-0003-4011-6633
Masato FujiiDepartment of Otolaryngology, Eiju General Hospital, Tokyo, Japan.
Ryuichi HayashiDivision of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Yasuhisa HasegawaDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Takashi FujiiDepartment of Head and Neck Surgery, Osaka International Cancer Institute, Osaka, Japan.
Kenji OkamiDepartment of Otolaryngology, Tokai University, Isehara, Kanagawa, Japan.
Akihiro HommaDepartment of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Tetsuro OnitsukaDepartment of Head and Neck Surgery, Shizuoka Cancer Center, Nagaizumi, Shizuoka, Japan.
Takakuni KatoDepartment of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.
Takenori OgawaDepartment of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kyoichi TeraoDepartment of Otolaryngology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
Nobuya MondenDepartment of Head and Neck surgery, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan.
Naoki OtsukiDepartment of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroshi NishinoDepartment of Otolaryngology and Head and Neck Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
Ichiro OtaDepartment of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Nara, Japan.
Yasushi FujimotoDepartment of Otolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuto MatsuuraDivision of Head and Neck Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan.
Kazuyoshi KawabataDepartment of Head and Neck Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Hidetoshi MatsuiDepartment of Head and Neck Surgery, Hyogo Cancer Center, 13-70 Kitaoji, Akashi, Hyogo, 673-8558, Japan.
Koichiro YonezawaDepartment of Head and Neck Surgery, Hyogo Cancer Center, 13-70 Kitaoji, Akashi, Hyogo, 673-8558, Japan.
Ken-Ichi NibuDepartment of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Hyogo Prefectural Cancer Center · JPKobe University · JPAichi Cancer Center · JPEiju General Hospital · JPHokkaido University · JPJapanese Foundation For Cancer Research · JPJichi Medical University · JPJikei University School of Medicine · JPKindai University · JPMiyagi Prefectural Hospital Organization · JPNagoya University · JPNara Medical University · JPNational Cancer Center Hospital East · JPOsaka International Cancer Institute · JPShikoku Cancer Center · JPShizuoka Cancer Center · JPTohoku University · JPTokai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to compare the therapeutic outcomes of total pharyngolaryngectomy with those of concomitant chemoradiotherapy in advanced hypopharyngeal cancer.

methodsThis is a retrospective multi-institutional study. The medical records of 979 patients with hypopharyngeal cancer, who were initially treated between 2006 and 2008, were reviewed. In this study, we matched a group of total pharyngolaryngectomy patients with a second group of chemoradiotherapy patients, according to age, gender, subsite, arytenoid fixation, cartilage invasion, and N classification, and analyzed overall survival, disease-specific survival, and locoregional control rates.

resultsThe matched-pair analysis included 254 patients. The 5-year overall survival, disease-specific survival, and locoregional control rates were 58.5% and 53.5% (P = 0.30), 68.9% and 68.0% (P = 0.80), and 82.2% and 63.6% (P < 0.01), respectively, for patients in the total pharyngolaryngectomy and chemoradiotherapy groups. For T4a patients with cartilage invasion, the matched-pair analysis included 46 patients. The 5-year overall survival, disease-specific, and locoregional control rates were 56.5% and 26.0% (P = 0.092), 56.5% and 41.3% (P = 0.629), and 43.0% and 42.5% (P = 0.779), respectively, for patients in the total pharyngolaryngectomy and chemoradiotherapy groups.

conclusionsThe data from this large-scale multi-institutional joint research program of hypopharyngeal cancer in Japan suggest that chemoradiotherapy may provide adequate survival benefit for hypopharyngeal cancer patients with the distinct advantage of larynx preservation. Our data also suggest that chemoradiotherapy is as beneficial as total pharyngolaryngectomy for the local control of locally advanced hypopharyngeal cancer.

Indexed as

AdultAgedAged, 80 and overAsian PeopleChemoradiotherapyDisease-Free SurvivalFemaleHumansHypopharyngeal NeoplasmsLaryngectomyLarynxMaleMatched-Pair AnalysisMiddle AgedOrgan Sparing TreatmentsPharyngectomyChemoradiotherapyHypopharyngeal cancerHypopharynxLarynx preservationPropensity score matchingSurvival

Identifiers

PMID28624863
OpenAlexW2626486573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.