ArticleEuropean journal of medicinal chemistry2017
Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study.
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Article in European journal of medicinal chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
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52 citing papers in PubMed, 89 citations in OpenAlex.
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- Targeting SARS-CoV-2 main protease: a pharmacophore and molecular modeling approach.Journal of molecular modeling · 2025Article
- Synthesis and Biological Activity of Glycosyl Thiazolyl Disulfides Based on Thiacarpine, an Analogue of the Cytotoxic Alkaloid Polycarpine from the AscidianMarine drugs · 2025Article
- 3-chymotrypsin-like protease in SARS-CoV-2.Bioscience reports · 2024Review
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- Consensus Pharmacophore Strategy For Identifying Novel SARS-Cov-2 MJournal of chemical information and modeling · 2024Article
- Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.European journal of medicinal chemistry · 2023Review
- An overview on medicinal plants used for combating coronavirus: Current potentials and challenges.Journal of agriculture and food research · 2023Article
- Screening, Synthesis and Biochemical Characterization of SARS-CoV-2 Protease Inhibitors.International journal of molecular sciences · 2023Article
- A Tale of Two Proteases: MPharmaceuticals (Basel, Switzerland) · 2023Review
- QSAR and molecular docking studies on designing potent inhibitors of SARS-CoVs main protease.Frontiers in pharmacology · 2023Article
- The exploration of phytocompounds theoretically combats SARS-CoV-2 pandemic against virus entry, viral replication and immune evasion.Journal of infection and public health · 2023Article
- Unsymmetrical aromatic disulfides as SARS-CoV-2 Mpro inhibitors: Molecular docking, molecular dynamics, and ADME scoring investigations.Journal of King Saud University. Science · 2022Article
- Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides.Molecules (Basel, Switzerland) · 2022Article
- Bis(thio)carbohydrazone Luminogens with AIEE and ACQ Features and TheirChemistrySelect · 2022Article
- In silico exploration of disulfide derivatives of Ferula foetida oleo-gum (Covexir®) as promising therapeutics against SARS-CoV-2.Computers in biology and medicine · 2022Article
- Antiviral Activity of Medicinal Plants against Human Coronavirus: a systematic scoping review of and experimentations.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Aromatic disulfides as potential inhibitors against interaction between deaminase APOBEC3G and HIV infectivity factor.Acta biochimica et biophysica Sinica · 2022Article
- A Patent Review on SARS Coronavirus Main Protease (3CLChemMedChem · 2022Review
- Screening of potential inhibitors targeting the main protease structure of SARS-CoV-2Frontiers in pharmacology · 2022Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Li WangState-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.
Bo-Bo BaoSchool of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
Guo-Qing SongState-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.
Cheng ChenSchool of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China. Electronic address: chengchen@tju.edu.cn.
Xu-Meng ZhangState-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.
Wei LuState-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China.
Zefang WangSchool of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
Yan CaiSchool of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
Shuang LiSchool of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
Sheng FuSchool of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
Fu-Hang SongCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Haitao YangSchool of Life Sciences, Tianjin University, Tianjin 300072, China; Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China.
Jian-Guo WangState-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China. Electronic address: nkwjg@nankai.edu.cn.
Nankai University · CNTianjin International Joint Academy of Biomedicine · CNTianjin University · CNChinese Academy of Sciences · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a high rate of mortality. Main protease (M
Indexed as
Drug DiscoveryMolecular Docking SimulationQuantitative Structure-Activity RelationshipAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesDisulfidesDose-Response Relationship, DrugHydrocarbons, AromaticMicrobial Sensitivity TestsMolecular StructureProtease InhibitorsSevere acute respiratory syndrome-related coronavirusViral ProteinsAntiviral AgentsCoronavirus 3C ProteasesCysteine EndopeptidasesDisulfidesHydrocarbons, AromaticProtease InhibitorsViral ProteinsAromatic disulfideIn vitro activityMolecular dockingSARS-CoV M(pro)
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