Evidence map›Paper›PMID 28624388›Full record

Observational studyThe Lancet. Respiratory medicine2017

Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.

John G Laffey, Fabiana Madotto, Giacomo Bellani, Tài Pham, Eddy Fan, Laurent Brochard, Pravin Amin, Yaseen Arabi, Ednan K Bajwa, Alejandro Bruhn and 22 more

3 registry-linked trialsOpen access · bronzeAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in The Lancet. Respiratory medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02010073 completednot on this map

A Multicentre, Prospective, Observational, 4-week Inception Cohort Study Being Carried Out by the Acute Respiratory Failure Section of ESICM

TypeobservationalSponsorEuropean Society of Intensive Care MedicineRan2014 to 2014Enrolled14,000ConditionsAcute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
NCT03415529 completednot on this mapstarted 2018, after this paper: background citation

Incidence of Hypercapnia and Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Respiratory Distress Syndrome (ARDS)

TypeobservationalSponsorEuropean Society of Intensive Care MedicineRan2018 to 2018Enrolled4,500ConditionsAcute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
NCT06288724 unknown statusnot on this mapstarted 2024, after this paper: background citation

Potentially MOdifiable Factors To ImproVe Outcomes of Mechanically Ventilated Patients in ICUs in a Low-income Country: Rationale and Protocol for a Registry-embedded Prospective Observational Study

Typeobservational_patient_registrySponsorNat Intensive Care Surveillance - MORURan2024 to 2024Enrolled625ConditionsCritical Illness, Invasive Mechanical Ventilation, ICU Mortality, Developing Countries
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Observational
  6. Article
  7. Observational
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Management of severe acute respiratory distress syndrome in Australia and New Zealand (SAGE-ANZ): An observational study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 19 countries.

John G LaffeyDepartment of Anesthesia, St Michael's Hospital, Toronto, ON, Canada; Department of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: laffeyj@smh.ca.
Fabiana MadottoResearch Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Giacomo BellaniResearch Center on Public Health, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.
Tài PhamKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Sorbonne Universités, UPMC Université Paris 06, Paris, France.
Eddy FanInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network and Mount Sinai Hospital, Toronto, ON, Canada.
Laurent BrochardKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Pravin AminDepartment of Critical Care Medicine, Bombay Hospital Institute of Medical Sciences, Mumbai, India.
Yaseen ArabiIntensive Care Department, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Respiratory Services, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Ednan K BajwaDivision of Pulmonary and Critical Care, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alejandro BruhnDepartamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Vladimir CernyDepartment of Anesthesiology, Perioperative Medicine and Intensive Care, J E Purkinje University, Masaryk Hospital, Usti nad Labem, Czech Republic; Department of Research and Development, and Department of Anesthesiology and Intensive Care, Charles University in Prague, Prague, Czech Republic; Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.
Kevin ClarksonDepartment of Anaesthesia, Galway University Hospitals and National University of Ireland, Galway, Galway, Ireland.
Leo HeunksDepartment of Intensive Care, VU University Medical Centre Amsterdam, Netherlands.
Kiyoyasu KurahashiDepartment of Anesthesiology and Intensive Care Medicine, School of Medicine, International University of Health and Welfare, Narita, Japan.
Jon Henrik LaakeDivision of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway.
Jose A LorenteCIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain.
Lia McNameeCentre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.
Nicolas NinCIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.
Jose Emmanuel PaloSection of Adult Critical Care, Department of Medicine, The Medical City, Pasig, Philippines.
Lise PiquilloudAdult Intensive Care and Burn Unit, University Hospital of Lausanne, Lausanne, Switzerland; Department of Medical Intensive Care, University Hospital of Angers, Angers, France.
Haibo QiuDepartment of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Juan Ignacio Silesky JiménezDepartment of Intensive Care, Hospital San Juan de Dios, and Department of Intensive Care, Hospital CIMA San Jose, Council of Critical Medicine, University of Costa Rica, San Pedro Montes de Oca, Costa Rica.
Andres EstebanCIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Hospital Español, Montevideo, Uruguay.
Daniel F McAuleyCentre for Experimental Medicine, Queen's University of Belfast, Belfast, Northern Ireland, UK; Wellcome-Wolfson Institute for Experimental Medicine, Belfast, Northern Ireland, UK; Regional Intensive Care Unit, Royal Victoria Hospital A&E, Grosvenor Road, Belfast, Northern Ireland, UK.
Frank van HarenIntensive Care Unit, Canberra Hospital, Canberra, ACT, Australia; Australian National University, Canberra, ACT, Australia.
Marco RanieriSapienza Università di Roma, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Rome, Italy.
Gordon RubenfeldInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, ON, Canada.
Hermann WriggeDepartment of Anesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany.
Arthur S SlutskyKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Antonio PesentiDipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico and Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.
LUNG SAFE Investigators
ESICM Trials Group
St. Michael's Hospital · CAQueen's University Belfast · GBUniversity of Milan · ITUniversity Hospital of Lausanne · CHHospital Universitario de Getafe · ESUniversidad de Costa Rica · CROslo University Hospital · NOPontificia Universidad Católica de Chile · CLUniversity of Asia and the Pacific · PHCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESAmsterdam UMC Location Vrije Universiteit Amsterdam · NLSunnybrook Health Science Centre · CAUniversity of Milano-Bicocca · ITZhongda Hospital Southeast University · CNAzienda Ospedaliera San Gerardo · ITCharles University · CZInternational University of Health and Welfare · JPKing Saud bin Abdulaziz University for Health Sciences · SAOllscoil na Gaillimhe – University of Galway · IEPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE).

methodsLUNG SAFE was done during 4 consecutive weeks in winter, 2014, in a convenience sample of 459 intensive-care units in 50 countries across six continents. Inclusion criteria were admission to a participating intensive-care unit (including transfers) within the enrolment window and receipt of invasive or non-invasive ventilation. One of the trial's secondary aims was to characterise variations in the demographics, management, and outcome of patients with ARDS. We used the 2016 World Bank countries classification to define three major geo-economic groupings, namely European high-income countries (Europe-High), high-income countries in the rest of the world (rWORLD-High), and middle-income countries (Middle). We compared patient outcomes across these three groupings. LUNG SAFE is registered with ClinicalTrials.gov, number NCT02010073.

findingsOf the 2813 patients enrolled in LUNG SAFE who fulfilled ARDS criteria on day 1 or 2, 1521 (54%) were recruited from Europe-High, 746 (27%) from rWORLD-High, and 546 (19%) from Middle countries. We noted significant geographical variations in demographics, risk factors for ARDS, and comorbid diseases. The proportion of patients with severe ARDS or with ratios of the partial pressure of arterial oxygen (PaO

interpretationImportant geo-economic differences exist in the severity, clinician recognition, and management of ARDS, and in patients' outcomes. Income per person and outcomes in ARDS are independently associated.

fundingEuropean Society of Intensive Care Medicine, St Michael's Hospital, University of Milan-Bicocca.

Indexed as

AgedComorbidityDelivery of Health CareDeveloped CountriesDeveloping CountriesEuropeFemaleGeography, MedicalHumansIncomeIntensive Care UnitsMaleMiddle AgedPatient Outcome AssessmentProspective StudiesRespiratory Distress Syndrome

Identifiers

PMID28624388
OpenAlexW2626627673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.