Evidence map›Paper›PMID 28624203›Full record

ArticleMolecular therapy. Nucleic acids2017

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia.

Jialei Yang, Xiufen Zhang, Xiangjie Chen, Lei Wang, Guodong Yang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07398612 (Clinical Study on the Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in the Treatment of Acute Ischemic Stroke), which is not on this map. Cited by 331 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed, 2 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07398612 phase1 / phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Clinical Study on the Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in the Treatment of Acute Ischemic Stroke

TypeinterventionalSponsorShanghai General Hospital, Shanghai Jiao Tong University School of MedicineRan2026 to 2028Enrolled60ConditionsAcute Ischemic StrokeArmsHuman Adipose-Derived Stem Cell Exosomes, Placebo
3 · Its place in the literature

Who cites it

331 citing papers in PubMed, 2 syntheses or guidelines pooled it, 583 citations in OpenAlex.

  1. Pooled it
  2. Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
    Pooled it
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271 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jialei YangDepartment of Neurology, New Era Stroke Care and Research Institute, The General Hospital of the PLA Rocket Force, 16 Xinjiekouwai Avenue, Beijing 100088, China; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University, 169 Changlexi Road, Xi'an, Shaanxi 710032, China.
Xiufen ZhangThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University, 169 Changlexi Road, Xi'an, Shaanxi 710032, China.
Xiangjie ChenDepartment of Mathematics, Southeast University, Nanjing 211189, China.
Lei WangDepartment of Neurology, New Era Stroke Care and Research Institute, The General Hospital of the PLA Rocket Force, 16 Xinjiekouwai Avenue, Beijing 100088, China. Electronic address: hellowanglei068@163.com.
Guodong YangThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University, 169 Changlexi Road, Xi'an, Shaanxi 710032, China. Electronic address: yanggd@fmmu.edu.cn.
Air Force Medical University · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intrinsic ability of neurogenesis after stroke has been proven weak, which results in insufficient repair of injury in the nerve system. Recent studies suggest multiple microRNAs (miRNAs) are involved in the neuroremodeling process. Targeted miRNAs delivery for amplification of neurogenesis is promising in promoting the prognosis after ischemia. Here, we showed that modified exosomes, with rabies virus glycoprotein (RVG) fused to exosomal protein lysosome-associated membrane glycoprotein 2b (Lamp2b), could efficiently deliver miR-124 to the infarct site. Systemic administration of RVG-exosomes loaded with miR-124 promoted cortical neural progenitors to obtain neuronal identity and protect against ischemic injury by robust cortical neurogenesis. Our study suggests that RVG-exosomes can be utilized therapeutically for the targeted delivery of gene drugs to the brain, thus having great potential for clinical applications.

Indexed as

exosomeischemiamiRNAneurogenesistargeted drug delivery

Identifiers

PMID28624203
PMCPMC5415550
OpenAlexW2607139744

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.