Evidence map›Paper›PMID 28624099›Full record

ReviewAtherosclerosis2017

Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.

Farzad Masoudkabir, Nizal Sarrafzadegan, Carolyn Gotay, Andrew Ignaszewski, Andrew D Krahn, Margot K Davis, Christopher Franco, Arya Mani

Open access · greenAbstract readReview
In one paragraph

Review in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 162 citations in OpenAlex.

  1. Pooled it
  2. The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Farzad MasoudkabirCardiac Primary Prevention Research Center, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Nizal SarrafzadeganIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: nsarrafzadegan@gmail.com.
Carolyn GotaySchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada; Cancer Control Research Program, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
Andrew IgnaszewskiDivision of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
Andrew D KrahnDivision of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
Margot K DavisDivision of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
Christopher FrancoDivision of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
Arya ManiYale Cardiovascular Genetics Program, Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
University of British Columbia · CAIsfahan University of Medical Sciences · IRTehran University of Medical Sciences · IRYale University · US

Funding

The Identification and characterization of genetic variants underlying cardiovascular diseasesR35HL135767 · NHLBI · YALE UNIVERSITY · PI MANI, ARYA · 2017 to 2023
$7.0M
NHLBI NIH HHS R35 HL135767
6 · The paper itself

Abstract

Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity worldwide. Strategies to improve their treatment and prevention are global priorities and major focus of World Health Organization's joint prevention programs. Emerging evidence suggests that modifiable risk factors including diet, sedentary lifestyle, obesity and tobacco use are central to the pathogenesis of both diseases and are reflected in common genetic, cellular, and signaling mechanisms. Understanding this important biological overlap is critical and may help identify novel therapeutic and preventative strategies for both disorders. In this review, we will discuss the shared genetic and molecular factors central to CVD and cancer and how the strategies commonly used for the prevention of atherosclerotic vascular disease can be applied to cancer prevention.

Indexed as

AnimalsAnticarcinogenic AgentsBiomarkers, TumorCardiovascular AgentsCardiovascular DiseasesCardiovascular SystemCell Transformation, NeoplasticGene Expression Regulation, NeoplasticHumansNeoplasmsRisk FactorsSignal TransductionAnticarcinogenic AgentsBiomarkers, TumorCardiovascular Agents

Identifiers

PMID28624099
PMCPMC6207942
OpenAlexW2621001223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.