ArticleVeterinary research2017
Differential protein expression in chicken macrophages and heterophils in vivo following infection with Salmonella Enteritidis.
Article in Veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Chicken heterophils as evolutionary models: insights into myeloperoxidase-independent antimicrobial strategies.Frontiers in immunology · 2026Review
- Corticosterone reprograms splenic responses to avian pathogenic Escherichia coli infection in broiler chickens.Poultry science · 2025Article
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- Comprehensive analysis of blood proteome response to necrotic enteritis in broiler chicken.Veterinary research · 2025Article
- Cellular landscape of avian intestinal organoids revealed by single cell transcriptomics.Scientific reports · 2025Article
- Transcriptomic and proteomic analysis reveals the mechanism of chicken cecum response toiScience · 2025Article
- Evaluation of myeloid-related protein 126, cardiac troponin C and serum amyloid A as potential plasma biomarkers of health and disease in sea turtles.Conservation physiology · 2025Article
- Single-cell RNA-seq mapping of chicken peripheral blood leukocytes.BMC genomics · 2024Article
- Chicken intestinal organoids: a novel method to measure the mode of action of feed additives.Frontiers in immunology · 2024Article
- Avian pathogenic Escherichia coli infection causes infiltration of heterophilic granulocytes of chick tracheal by the complement and coagulation cascades pathway.BMC veterinary research · 2023Article
- The immune cell landscape and response of Marek's disease resistant and susceptible chickens infected with Marek's disease virus.Scientific reports · 2023Article
- The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential.Frontiers in immunology · 2023Review
- Practical application of a Bayesian network approach to poultry epigenetics and stress.BMC bioinformatics · 2022Article
- Long-chain glucomannan supplementation modulates immune responsiveness, as well as intestinal microbiota, and impacts infection of broiler chickens with Salmonella enterica serotype Enteritidis.Veterinary research · 2022Article
- Host Antiviral Responses against Avian Infectious Bronchitis Virus (IBV): Focus on Innate Immunity.Viruses · 2021Review
- A detailed analysis of innate and adaptive immune responsiveness upon infection with Salmonella enterica serotype Enteritidis in young broiler chickens.Veterinary research · 2021Article
- Effects of lysine biomass supplementation on growth performance and clinical indicators in broiler chickens.Poultry science · 2021Article
- Three-Dimensional Avian Hematopoietic Stem Cell Cultures as a Model for Studying Disease Pathogenesis.Frontiers in cell and developmental biology · 2021Review
- Novel Models for Chronic Intestinal Inflammation in Chickens: Intestinal Inflammation Pattern and Biomarkers.Frontiers in immunology · 2021Article
- Proper Immune Response Depends on Early Exposure to Gut Microbiota in Broiler Chicks.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study we compared the proteomes of macrophages and heterophils isolated from the spleen 4 days after intravenous infection of chickens with Salmonella Enteritidis. Heterophils were characterized by expression of MMP9, MRP126, LECT2, CATHL1, CATHL2, CATHL3, LYG2, LYZ and RSFR. Macrophages specifically expressed receptor proteins, e.g. MRC1L, LRP1, LGALS1, LRPAP1 and a DMBT1L. Following infection, heterophils decreased ALB and FN1, and released MMP9 to enable their translocation to the site of infection. In addition, the endoplasmic reticulum proteins increased in heterophils which resulted in the release of granular proteins. Since transcription of genes encoding granular proteins did not decrease, these genes remained continuously transcribed and translated even after initial degranulation. Macrophages increased amounts of fatty acid elongation pathway proteins, lysosomal and phagosomal proteins. Macrophages were less responsive to acute infection than heterophils and an increase in proteins like CATHL1, CATHL2, RSFR, LECT2 and GAL1 in the absence of any change in their expression at RNA level could even be explained by capturing these proteins from the external environment into which these could have been released by heterophils.
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Registered trials
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