Trial reportBMC women's health2017
Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: results from a randomized controlled trial in Vietnam.
Trial report in BMC women's health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01665378 (Impact of Pre-Pregnancy Micronutrient Supplementation on Maternal and Child Outcomes), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Pre-Pregnancy Micronutrient Supplementation on Maternal and Child Outcomes
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Effect of preconception multiple micronutrients vs. iron-folic acid supplementation on maternal and birth outcomes among women from developing countries: a systematic review and meta-analysis.Frontiers in nutrition · 2024Pooled it
- Effectiveness of preconception interventions in primary care: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Pooled it
- Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Home environment and nutritional status mitigate the wealth gap in child development: a longitudinal study in Vietnam.BMC public health · 2023Trial
- Article
- School-Based Weekly Iron-Folic Acid Supplementation and Its Effect on Mental Health Outcomes Among Adolescent Girls in Central Ethiopia: A Cluster-Randomized Controlled Trial.Journal of nutrition and metabolism · 2026Article
- Effects of preconception nutrition interventions on pregnancy and birth outcomes in South Asia: a systematic review.The Lancet regional health. Southeast Asia · 2025Review
- Holistic perinatal care during intimate examinations: An integrative review.Health SA = SA Gesondheid · 2025Review
- Determinants and Prevalence of Depression Among Dietary Supplement Users in Saudi Arabia: A Cross-Sectional Study.Cureus · 2024Article
- Measurement invariance of the Center for Epidemiologic Studies Scale-Depression within and across six diverse intervention trials.Psychological assessment · 2023Article
- Advances in Folic Acid Biosensors and Their Significance in Maternal, Perinatal, and Paediatric Preventive Medicine.Biosensors · 2023Review
- Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators.Frontiers in psychiatry · 2023Article
- Pregnant women's experiences of well-being in high-risk pregnancy: A qualitative study.Journal of education and health promotion · 2023Article
- Vitamins and minerals, education, and self-care need during preconception to 1000 days of life in Southeast Asia: An expert panel opinion.SAGE open medicine · 2023Review
- Development and psychometric evaluation of the High-Risk Pregnancy Well-Being Index in Mashhad: a methodological study.Reproductive health · 2022Article
- Dietary Supplementations and Depression.Journal of multidisciplinary healthcare · 2022Review
- Effects of vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2021Article
- Well-being in high-risk pregnancy: an integrative review.BMC pregnancy and childbirth · 2020Review
- Can broad-spectrum multinutrients treat symptoms of antenatal depression and anxiety and improve infant development? Study protocol of a double blind, randomized, controlled trial (the 'NUTRIMUM' trial).BMC pregnancy and childbirth · 2020Article
- Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries.Annals of the New York Academy of Sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicronutrient malnutrition has been associated with maternal depressive symptoms (MDS), but little is known about the effects of preconceptional micronutrient supplementation. This paper examined the effects of preconceptional micronutrient supplementation on MDS during pregnancy and postpartum.
methodsWe used data from a double-blind controlled trial (PRECONCEPT) in which 5011 Vietnamese women were randomized to receive weekly supplements containing either a) multiple micronutrients (MM) b) iron and folic acid (IFA) or c) folic acid (FA) until conception (n = 1813). Maternal mental health was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) at baseline (preconception), and the Edinburgh Postnatal Depression Scale (EPDS) during pregnancy and 3 months postpartum. Elevated MDS was defined as EPDS score ≥ 4. All group comparisons were done using ANOVA or chi-square tests of proportions intention to treat and per protocol analyses (women consumed supplements ≥26 weeks before conception). We also conducted stratified analyses by preconception CES-D scores, underweight, or anemia status using generalized linear models.
resultsBaseline CES-D scores were similar across treatment groups. The proportion of women experiencing elevated MDS was 11.3, 8.1 and 4.9% at first, second and third trimesters of pregnancy, respectively, and 3.6% at 3 mo postpartum. Mean EPDS scores at first (1.5 ± 2.7), second (1.1 ± 2.4), and third trimester of pregnancy (0.7 ± 2.0) and early postpartum (0.6 ± 1.8) were low and did not differ by treatment group. However, among women in the highest tertile of CES-D scores at preconception, mean EPDS scores in the first and second trimesters of pregnancy were lower in the MM and IFA groups compared to FA only (P < 0.05).
conclusionsWeekly preconceptional micronutrient supplements containing iron did not improve depression measures relative to folic acid alone among all women, but may have benefitted women who were at risk for depression.
trial registrationThe trial was registered retrospectively at ClinicalTrials.Gov as NCT01665378 on August 13, 2012.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.