Evidence map›Paper›PMID 28623807›Full record

ArticleDrug and alcohol dependence2017

HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens.

G Cristina Brailoiu, Elena Deliu, Jeffrey L Barr, Linda M Console-Bram, Alexandra M Ciuciu, Mary E Abood, Ellen M Unterwald, Eugen Brailoiu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Adam, amigo, brain, and K channel.Biophysical reviews · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. [The Journal of pharmacology and experimental therapeutics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

G Cristina BrailoiuDepartment of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Elena DeliuCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Jeffrey L BarrCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Linda M Console-BramCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Alexandra M CiuciuCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Mary E AboodCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Ellen M UnterwaldCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address: ellen.unterwald@temple.edu.
Eugen BrailoiuCenter for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address: ebrailou@temple.edu.
Temple University · USThomas Jefferson University · US

Funding

Pilot Projects Core (PPC)P30DA013429 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI Munir Gunes Kutlu · 2000 to 2026
$34.6M
Molecular Characterization of GPR35 and GPR55, Putative Cannabinoid ReceptorsR01DA023204 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI ABOOD, MARY E · 2007 to 2016
$3.2M
Functional Role for GPR55 in the periaqueductal grayR01DA035926 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI ABOOD, MARY E, BENAMAR, KHALID · 2014 to 2018
$1.6M
NIDA NIH HHS P30 DA013429NIDA NIH HHS R01 DA023204NIDA NIH HHS R01 DA035926
6 · The paper itself

Abstract

backgroundHIV-1 infection and drug abuse are frequently co-morbid and their association greatly increases the severity of HIV-1-induced neuropathology. While nucleus accumbens (NAcc) function is severely perturbed by drugs of abuse, little is known about how HIV-1 infection affects NAcc.

methodsWe used calcium and voltage imaging to investigate the effect of HIV-1 trans-activator of transcription (Tat) on rat NAcc. Based on previous neuronal studies, we hypothesized that Tat modulates intracellular Ca

resultsWe provide evidence that Tat triggers a Ca

conclusionWe describe for the first time a HIV-1 Tat-triggered Ca

Indexed as

AnimalsCalciumCells, CulturedCocaineDose-Response Relationship, DrugDrug SynergismFemaleMaleNeuronsNucleus AccumbensRatsReceptors, Dopamine D1Signal TransductionSodiumtat Gene Products, Human Immunodeficiency VirusCalciumCocaineReceptors, Dopamine D1Sodiumtat Gene Products, Human Immunodeficiency VirusCalcium imagingCalcium influxDepolarizationIntracellular calcium mobilizationMedium spiny neuronsTRPC

Identifiers

PMID28623807
PMCPMC5797705
OpenAlexW2623883725

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.