Evidence map›Paper›PMID 28623663›Full record

ArticleeLife2017

Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.

Yan Han, Chunli Yan, Thi Hoang Duong Nguyen, Ashleigh J Jackobel, Ivaylo Ivanov, Bruce A Knutson, Yuan He

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 80 citations in OpenAlex.

  1. The molecular basis of transcription initiation by RNA polymerase II.Nature reviews. Molecular cell biology · 2026
    Review
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  14. Cryo-EM structures of human RNA polymerase I.Nature structural & molecular biology · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Review
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  20. Structure of human RNA polymerase III.Nature communications · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yan HanDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0002-1207-7756
Chunli YanDepartment of Chemistry, Georgia State University, Atlanta, United States.
Thi Hoang Duong NguyenHoward Hughes Medical Institute, University of California, Berkeley, United States.
Ashleigh J JackobelDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, United States.
Ivaylo IvanovDepartment of Chemistry, Georgia State University, Atlanta, United States.
Bruce A KnutsonDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, United States.ORCID 0000-0003-3599-1302
Yuan HeDepartment of Molecular Biosciences, Northwestern University, Evanston, United States.ORCID 0000-0002-1455-3963
Georgia State University · USNorthwestern University · USSUNY Upstate Medical University · USHoward Hughes Medical Institute · US

Funding

Integrative modeling of PCNA assemblies engaged in genome duplication and repairR01GM110387 · NIGMS · GEORGIA STATE UNIVERSITY · PI IVANOV, IVAYLO NIKOLAEV · 2015 to 2019
$1.7M
Molecular mechanism of RNA polymerase I transcription and dysregulation in cancerK22CA184235 · NCI · UPSTATE MEDICAL UNIVERSITY · PI KNUTSON, BRUCE ALAN · 2014 to 2016
$634k
NCI NIH HHS K22 CA184235NIGMS NIH HHS R01 GM110387
6 · The paper itself

Abstract

Transcription initiation by RNA Polymerase I (Pol I) depends on the Core Factor (CF) complex to recognize the upstream promoter and assemble into a Pre-Initiation Complex (PIC). Here, we solve a structure of

Indexed as

Transcription Initiation, GeneticCryoelectron MicroscopyDNA, FungalPol1 Transcription Initiation Complex ProteinsProtein BindingRNA Polymerase ISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA, FungalPol1 Transcription Initiation Complex ProteinsRNA Polymerase IRRN7 protein, S cerevisiaeSaccharomyces cerevisiae Proteinsbiophysicscore factorgene expressioninitiation complexribosomal RNARNA polymerase IS. cerevisiaestructural biologytranscription

Identifiers

PMID28623663
PMCPMC5489313
OpenAlexW2626263331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.