Evidence map›Paper›PMID 28623613›Full record

ArticleSports medicine (Auckland, N.Z.)2018

Assessment of Metabolic Flexibility by Means of Measuring Blood Lactate, Fat, and Carbohydrate Oxidation Responses to Exercise in Professional Endurance Athletes and Less-Fit Individuals.

Iñigo San-Millán, George A Brooks

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Sports medicine (Auckland, N.Z.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07484776 (Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer and the Possible Effect of a Physical Exercise Intervention), which is not on this map. Cited by 152 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 6 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07484776 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer and the Possible Effect of a Physical Exercise Intervention

TypeinterventionalSponsorUniversidad Europea de MadridRan2026 to 2028Enrolled40ConditionsTriple-Negative Breast Cancer (TNBC)ArmsCardiovascular training at maximal fat oxidation (FATmax), Cardiovascular training at maximal aerobic power (MAP), Resistance training
3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 6 syntheses or guidelines pooled it, 239 citations in OpenAlex.

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  9. Successfully Reducing Sitting Time Can Improve Metabolic Flexibility.Scandinavian journal of medicine & science in sports · 2025
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92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Iñigo San-MillánDepartment of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, CO, USA. inigo.sanmillan@ucdenver.edu.
George A BrooksExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkley, CA, USA.
University of California, Berkeley · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased muscle mitochondrial mass is characteristic of elite professional endurance athletes (PAs), whereas increased blood lactate levels (lactatemia) at the same absolute submaximal exercise intensities and decreased mitochondrial oxidative capacity are characteristics of individuals with low aerobic power. In contrast to PAs, patients with metabolic syndrome (MtS) are characterized by a decreased capacity to oxidize lipids and by early transition from fat to carbohydrate oxidation (FATox/CHOox), as well as elevated blood lactate concentration [La

objectiveThe aim of this study was to assess metabolic flexibility across populations with different metabolic characteristics.

methodsWe used indirect calorimetry and [La

resultsFATox was significantly higher in PAs than MAs and patients with MtS (p < 0.01), while [La

conclusionsBlood lactate accumulation is negatively correlated with FATox and positively correlated with CHOox during exercise across populations with widely ranging metabolic capabilities. Because both lactate and fatty acids are mitochondrial substrates, we believe that measurements of [La

Indexed as

AthletesCarbohydrate MetabolismEnergy MetabolismExerciseExercise TestHumansLactatesLipid MetabolismMaleOxidation-ReductionOxygen ConsumptionPhysical EnduranceLactates

Identifiers

PMID28623613
OpenAlexW2624787623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.