Evidence map›Paper›PMID 28623399›Full record

ArticleRadiation and environmental biophysics2017

Endothelial dysfunction in rectal cancer patients chronically exposed to ionizing radiation.

Tolebay Rakhypbekov, Ken Inoue, Laura Pak, Noriyuki Kawano, Nobuo Takeichi, Masaharu Hoshi, Yoshihiro Noso, Nailya Chaizhunusova, Zukhra Manambayeva, Arman Khozhayev and 4 more

Abstract read
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In one paragraph

Article in Radiation and environmental biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Tolebay RakhypbekovSemey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Ken InoueHealth Service Center, Kochi University, 2-5-1, Akebono-cho, Kochi-shi, Kochi, 780-8520, Japan. ke-inoue@med.shimane-u.ac.jp.
Laura PakSemey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Noriyuki KawanoHiroshima University, Hiroshima, 734-8553, Japan.
Nobuo TakeichiTakeichi Clinic, Hiroshima, 732-0806, Japan.
Masaharu HoshiHiroshima University, Hiroshima, 734-8553, Japan.
Yoshihiro NosoDepartment of General Surgery, Faculty of Medicine, Shimane University, Shimane, 693-8501, Japan.
Nailya ChaizhunusovaSemey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Zukhra ManambayevaSemey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Arman KhozhayevDepartment of Oncology, The Kazakh National Medical University of S.D.Asfendiyarov, Tole Bi St. 94, Almaty, Kazakhstan.
Maulen MolgazhdarovDepartment of Oncology, The Kazakh National Medical University of S.D.Asfendiyarov, Tole Bi St. 94, Almaty, Kazakhstan.
Sayakhat OlzhaevDepartment of Oncology, Almaty Regional Oncologic Hospital, Demchenko Str., 83, Almaty, Kazakhstan.
Sholpan TokanovaSemey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Madina MadiyevaSemey State Medical University, Abay Str. 103, Semey, 071400, Kazakhstan.
Semey Medical University · KZHiroshima University · JPKazakh National Medical University · KZKazakh Institute of Oncology and Radiology · KZKōchi University · JPShimane University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We sought to identify the features of endothelial function in rectal cancer patients who were exposed to chronic ionizing radiation from a nuclear test site in Kazakhstan. We examined 146 individuals, 76 of whom were rectal cancer patients. The existence of a complex of disturbances of the endothelium and hemostasis systems in patients vs non-patients was revealed. Endothelial dysfunction was expressed as an increase of nitric oxide (NO) production along with decreases in vasodilatation function, and increased levels of von Willebrand factor in blood, along with an increase in the number of circulating endotheliocytes. Significant correlations between indicators of endothelial function and vascular-platelet hemostasis were observed. These changes and their interrelations were expressed more strongly in the patients who lived in the contaminated area around the nuclear test site. Such patients could have an increased risk of thrombosis and other complications after the treatment of a malignant neoplasm.

Indexed as

AgedBlood PlateletsCase-Control StudiesEndothelium, VascularFemaleHumansMaleMiddle AgedNeoplasms, Radiation-InducedRadiation ExposureRectal NeoplasmsEndothelial dysfunctionRadiationRectal cancerRisk

Identifiers

PMID28623399
OpenAlexW2626283239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.