Evidence map›Paper›PMID 28623388›Full record

ArticleEuropean biophysics journal : EBJ2018

Lateral diffusion and signaling of receptor for advanced glycation end-products (RAGE): a receptor involved in chronic inflammation.

Aleem Syed, Qiaochu Zhu, Emily A Smith

Abstract read
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In one paragraph

Article in European biophysics journal : EBJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. RAGE Signaling in Melanoma Tumors.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Aleem SyedDepartment of Chemistry, Iowa State University, 1605 Gilman Hall, Ames, IA, 50011, USA.
Qiaochu ZhuDepartment of Chemistry, Iowa State University, 1605 Gilman Hall, Ames, IA, 50011, USA.
Emily A SmithDepartment of Chemistry, Iowa State University, 1605 Gilman Hall, Ames, IA, 50011, USA. esmith1@iastate.edu.
Iowa State University · US

Funding

National Science Foundation CHE-1412084
6 · The paper itself

Abstract

Membrane diffusion is one of the key mechanisms in the cellular function of receptors. The signaling of receptors for advanced glycation end-products (RAGE) has been extensively studied in the context of several pathological conditions, however, very little is known about RAGE diffusion. To fill this gap, RAGE lateral diffusion is probed in native, cholesterol-depleted, and cytoskeleton-altered cellular conditions. In native GM07373 cellular conditions, RAGE has a 90% mobile fraction and an average diffusion coefficient of 0.3 μm

Indexed as

Signal TransductionActin CytoskeletonAnimalsCattleCell LineCell MembraneChronic DiseaseDiffusionInflammationReceptor for Advanced Glycation End ProductsReceptor for Advanced Glycation End ProductsActin cytoskeletonCell membrane biophysicsCholesterol depletionFluorescence recovery after photobleachingPhosphorylation of ERK

Identifiers

PMID28623388
OpenAlexW2625161673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.