ArticleNeuropharmacology2017
Mutation of the inhibitory ethanol site in GABA
Open access · greenAbstract read
In one paragraph
Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice.Molecular psychiatry · 2024Article
- Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications.Frontiers in pharmacology · 2024Review
- Changes in Memory, Sedation, and Receptor Kinetics Imparted by the β2-N265M and β3-N265M GABAInternational journal of molecular sciences · 2023Article
- Prenatal and adolescent alcohol exposure programs immunity across the lifespan: CNS-mediated regulation.Pharmacology, biochemistry, and behavior · 2022Review
- A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hippocampal β2-GABAJournal of neurophysiology · 2021Article
- Reduced sedation and increased ethanol consumption in knock-in mice expressing an ethanol insensitive alpha 2 subunit of the glycine receptor.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- A long non-coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats.Genes, brain, and behavior · 2021Review
- Cellular interactions between social experience, alcohol sensitivity, and GABAergic inhibition in a crayfish neural circuit.Journal of neurophysiology · 2021Article
- Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain sciences · 2020Review
- Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring.Brain sciences · 2020Article
- Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice with Increased Astrocyte Expression of IL-6.Neuroscience · 2020Article
- MUNC13-1 heterozygosity does not alter voluntary ethanol consumption or sensitivity in mice.Alcohol (Fayetteville, N.Y.) · 2020Article
- Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure.Alcohol (Fayetteville, N.Y.) · 2020Article
- The Cerebellum on Cocaine.Frontiers in systems neuroscience · 2020Review
- Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.Genes, brain, and behavior · 2019Article
- Molecular tools to elucidate factors regulating alcohol use.Alcohol (Fayetteville, N.Y.) · 2019Review
- Gene-edited CRISPy Critters for alcohol research.Alcohol (Fayetteville, N.Y.) · 2019Review
- Identification of a Functional Non-coding Variant in the GABAFrontiers in genetics · 2019Article
- Effects of ethanol and ethanol metabolites on intrinsic function of mesenteric resistance arteries.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Yuri A BlednovThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712, United States.
Cecilia M BorgheseThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712, United States.
Carlos I RuizThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712, United States.
Madeline A CullinsThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712, United States.
Adriana Da CostaThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712, United States.
Elizabeth A Osterndorff-KahanekThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712, United States.
Gregg E HomanicsUniversity of Pittsburgh, Departments of Anesthesiology, Neurobiology, and Pharmacology & Chemical Biology, Pittsburgh, PA 15261, United States.
R Adron HarrisThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712, United States. Electronic address: harris@austin.utexas.edu.
The University of Texas at Austin · USUniversity of Pittsburgh · US
Funding
INIA: ANIMAL COREU01AA013520 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI YURI A BLEDNOV, ROBERT O. MESSING · 2001 to 2026
$9.5MBRAIN MEMBRANES IN ALCOHOL AND BENZODIAZEPINE DEPENDENCER01AA006399 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI HARRIS, ROBERT A · 1985 to 2018
$8.8MRole of noncoding RNA in alcohol actionU01AA020889 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sean P Farris, Gregg E. Homanics · 2011 to 2026
$7.1MEthanol Mechanisms in GABAAR Gene Targeted MiceR37AA010422 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOMANICS, GREGG E. · 2010 to 2019
$4.4METHANOL MECHANISMS IN GABAAR GENE TARGETED MICER01AA010422 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOMANICS, GREGG E. · 1995 to 2008
$3.1MBRAIN MEMBRANES IN ALCOHOL AND BENZODIAZEPINE DEPENDENCER37AA006399 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI HARRIS, ROBERT ADRON · 1989 to 1998
–NIAAA NIH HHS R01 AA006399NIAAA NIH HHS R01 AA010422NIAAA NIH HHS R37 AA006399NIAAA NIH HHS R37 AA010422NIAAA NIH HHS U01 AA013520NIAAA NIH HHS U01 AA020889
Abstract
Genes encoding the ρ1/2 subunits of GABA
Indexed as
Alcoholic IntoxicationAnimalsAtaxiaCentral Nervous System DepressantsCerebellumCRISPR-Cas SystemsEthanolFemaleHumansMaleMice, TransgenicMotor ActivityMutationOocytesReceptors, GABA-ARecovery of FunctionCentral Nervous System DepressantsEthanolGABRR1 protein, humanGabrr1 protein, mouseGabrr2 protein, mouseReceptors, GABA-ARNA, MessengerAcute functional toleranceEthanol-induced motor impairmentGABA(A) rho1 receptorXenopus oocytesρ1 Knockin and knockout mice
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.