Evidence map›Paper›PMID 28622506›Full record

ReviewCell2017

Dynamic RNA Modifications in Gene Expression Regulation.

Ian A Roundtree, Molly E Evans, Tao Pan, Chuan He

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2,142 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,142citing papers in PubMed, 1 pooled it
83.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2,142 citing papers in PubMed, 1 synthesis or guideline pooled it, 3,481 citations in OpenAlex.

  1. Pooled it
  2. Systems metabolic engineering of a plasmid-freeSynthetic and systems biotechnology · 2027
    Article
  3. Optimized GLORI-Seq of Chromatin-Associated RNAs.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. mApplied biochemistry and biotechnology · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Methyltransferase RsmB chaperonesScience advances · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. RNA mActa pharmacologica Sinica · 2026
    Review

2,082 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ian A RoundtreeDepartment of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA; Medical Scientist Training Program, The University of Chicago, 924 East 57(th) Street, Chicago, IL 60637, USA.
Molly E EvansDepartment of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA.
Tao PanDepartment of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA. Electronic address: taopan@uchicago.edu.
Chuan HeDepartment of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA; Department of Chemistry, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57(th) Street, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.
University of Chicago · USHoward Hughes Medical Institute · US

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Predoctoral Training Program in Chemistry & BiologyT32GM008720 · NIGMS · UNIVERSITY OF CHICAGO · PI PICCIRILLI, JOSEPH ANTHONY · 1999 to 2020
$4.7M
N6-methyladenosine-dependent regulation of gene expression by YTHDC1F30GM117646 · NIGMS · UNIVERSITY OF CHICAGO · PI ROUNDTREE, IAN · 2016 to 2016
$49k
NHGRI NIH HHS RM1 HG008935NIGMS NIH HHS F30 GM117646NIGMS NIH HHS T32 GM007281NIGMS NIH HHS T32 GM008720
6 · The paper itself

Abstract

Over 100 types of chemical modifications have been identified in cellular RNAs. While the 5' cap modification and the poly(A) tail of eukaryotic mRNA play key roles in regulation, internal modifications are gaining attention for their roles in mRNA metabolism. The most abundant internal mRNA modification is N

Indexed as

Gene Expression RegulationRNA Processing, Post-TranscriptionalAnimalsHumansNucleotidesRNANucleotidesRNA

Identifiers

PMID28622506
PMCPMC5657247
OpenAlexW2627064270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.