Evidence map›Paper›PMID 28622501›Full record

ArticleCell2017

Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria.

Jan Gruber, Brian K Kennedy

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  3. Genetic insights into the gut microbiota and risk of facial skin aging: A Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
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  11. Strain-Specific Effects ofInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jan GruberDepartment of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore, National University of Singapore, MD 7, 8 Medical Drive, Singapore 117596, Singapore; Ageing Research Laboratory, Science Division, Yale-NUS College, Singapore 138527, Singapore.
Brian K KennedyDepartment of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore, National University of Singapore, MD 7, 8 Medical Drive, Singapore 117596, Singapore; Department of Physiology, Yong Loo Lin School of Medicine National University of Singapore, National University of Singapore, MD 9, 2 Medical Drive, Singapore 117596, Singapore; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: bkennedy@buckinstitute.org.
Buck Institute for Research on Aging · USNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microbiome has emerged as a major determinant of the functioning of host organisms, affecting both health and disease. Here, Han et al. use the workhorse of aging research, C. elegans, to identify specific mechanisms by which gut bacteria influence mitochondrial dynamics and aging, a first step toward analogous manipulations to modulate human aging.

Indexed as

LongevityAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsHumansMicrobiotaMitochondriaCaenorhabditis elegans Proteins

Identifiers

PMID28622501
OpenAlexW2625290695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.