ArticlePloS one2017
Antibiotic prophylaxis for surgical site infections as a risk factor for infection with Clostridium difficile.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Trial
- FulminantAnnals of hepato-biliary-pancreatic surgery · 2026Article
- CCL3 and LPS combination therapy significantly reduces infection and stimulates wound healing in diabetic mice by boosting proinflammatory responses.The Journal of investigative dermatology · 2026Article
- Perioperative antibiotic prophylaxis in robotic-assisted ventral hernia repair: a propensity score-matched analysis.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Beta-lactam allergy risk stratification in a maternity population in Australia: Scope for allergy de-labelling.The Australian & New Zealand journal of obstetrics & gynaecology · 2024Article
- Antibiotic Stewardship in Surgical Departments.Antibiotics (Basel, Switzerland) · 2024Review
- Clostridioides difficile infection in neurosurgical patients in a national centre over 10 years: less common but associated with longer hospital stays.Acta neurochirurgica · 2023Article
- Impact of Perioperative Prophylaxis WithTransplantation direct · 2023Article
- Strategies to prevent surgical site infections in acute-care hospitals: 2022 Update.Infection control and hospital epidemiology · 2023Article
- Penicillin allergy delabeling: Opportunities for implementation and dissemination.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023Review
- Review
- Postdischarge prophylactic antibiotics following mastectomy with and without breast reconstruction.Infection control and hospital epidemiology · 2022Article
- Article
- Lack of association of post-discharge prophylactic antibiotics with decreased risk of surgical site infection following spinal fusion.The Journal of antimicrobial chemotherapy · 2022Article
- Suspected allergy to Beta-Lactam antibiotics: An infectiological perspective.Allergologie select · 2022Review
- Article
- Antimicrobial Prophylaxis in Clean Pediatric Surgical Procedures: A Necessity or Redundancy?Cureus · 2020Article
- Postdischarge antibiotic use for prophylaxis following spinal fusion.Infection control and hospital epidemiology · 2020Article
- Hospital Infection Control:Clinics in colon and rectal surgery · 2020Review
- [Multicenter study of adherence to guidelines on surgical prophylaxis and the determinants of non-adherence in ArgentinaEstudo multicêntrico sobre a adesão a diretrizes de profilaxia cirúrgica e seus determinantes na Argentina].Revista panamericana de salud publica = Pan American journal of public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to measure the association between 2013 guideline concordant prophylactic antibiotic use prior to surgery and infection with Clostridium difficile.
designWe conducted a retrospective case-control study by selecting patients who underwent a surgical procedure between January 1, 2012 and December 31, 2013.
settingLarge urban community hospital. PATIENTS: Cases and controls were patients age 18+ years who underwent an eligible surgery (i.e., colorectal, neurosurgery, vascular/cardiac/thoracic, hysterectomy, abdominal/pelvic and orthopedic surgical procedures) within six months prior to infection diagnosis. Cases were diagnosed with C. difficile infection while controls were not.
methodsThe primary exposure was receiving (vs. not receiving) the recommended prophylactic antibiotic regimen, based on type and duration. Potential confounders included age, sex, length of hospital stay, comorbidities, type of surgery, and prior antibiotic use. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression.
resultsWe enrolled 68 cases and 220 controls. The adjusted OR among surgical patients between developing C. difficile infection and not receiving the recommended prophylactic antibiotic regimen (usually receiving antimicrobial prophylaxis for more than 24 hours) was 6.7 (95% CI: 2.9-15.5). Independent risk factors for developing C. difficile infection included having severe comorbidities, receiving antibiotics within the previous 6 months, and undergoing orthopedic surgery.
conclusionsAdherence to the recommended prophylactic antibiotics among surgical patients likely reduces the probability of being case of C. difficile. Antibiotic stewardship should be a priority in strategies to decrease the morbidity, mortality, and costs associated with C. difficile infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.