Evidence map›Paper›PMID 28622169›Full record

ReviewCurrent opinion in allergy and clinical immunology2017

Molecular aspects of allergens in atopic dermatitis.

Raffaela Campana, Sheron Dzoro, Irene Mittermann, Elena Fedenko, Olga Elisyutina, Musa Khaitov, Alexander Karaulov, Rudolf Valenta

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Observational
  2. Revisiting Atopy: The IgE-Dependent Amplification Loop as a Forgotten Driver of Atopic Dermatitis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Aeroallergens in Atopic Dermatitis and Chronic Urticaria.Current allergy and asthma reports · 2022
    Review
  10. Review
  11. [Treatment of atopic dermatitis with dupilumab : A retrospective cohort analysis from dermatological practice].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Position Statement on Atopic Dermatitis in Sub-Saharan Africa: current status and roadmap.Journal of the European Academy of Dermatology and Venereology : JEADV · 2019
    Article
  18. Article
  19. Article
  20. Autoimmunity (or Not) in Atopic Dermatitis.Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Raffaela CampanaaDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria bNRC Institute of Immunology FMBA cDepartment of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.
Sheron Dzoro
Irene Mittermann
Elena Fedenko
Olga Elisyutina
Musa Khaitov
Alexander Karaulov
Rudolf Valenta
Medical University of Vienna · ATInstitute of Immunology · HRSechenov University · RU

Funding

Austrian Science Fund FWF F 4605
6 · The paper itself

Abstract

purpose of reviewMolecular allergology uses pure, mainly recombinant and structurally defined allergen molecules and allergen-derived epitopes to study mechanisms of IgE-associated allergy, to diagnose, and even predict the development of allergic manifestations and to treat and prevent IgE-associated allergies. Atopic dermatitis, a chronic inflammatory skin disease is almost always associated with IgE sensitization to allergens. However, also non-IgE-mediated pathomechanisms seem to be operative in atopic dermatitis and it is often difficult to identify the disease-causing allergens. Here we review recent work showing the usefulness of molecular allergology to study mechanisms of atopic dermatitis, for diagnosis and eventually for treatment and prevention of atopic dermatitis. RECENT

findingsIgE sensitization to airborne, food-derived, microbial allergens, and autoallergens has been found to be associated with atopic dermatitis. Using defined allergen molecules and non-IgE-reactive allergen derivatives, evidence could be provided for the existence of IgE- and non-IgE-mediated mechanisms of inflammation in atopic dermatitis. Furthermore, effects of epicutaneous allergen administration on systemic allergen-specific immune responses have been studied. Multi-allergen tests containing micro-arrayed allergen molecules have been shown to be useful for the identification of culprit allergens in atopic dermatitis and may improve the management of atopic dermatitis by allergen-specific immunotherapy, allergen avoidance, and IgE-targeting therapies in a personalized medicine approach. SUMMARY: Molecular allergology allows for dissection of the pathomechanisms of atopic dermatitis, provides new forms of allergy diagnosis for identification of disease-causing allergens, and opens the door to new forms of management by allergen-specific and T cells-targeting or IgE-targeting interventions in a personalized medicine approach.

Indexed as

AllergensAnimalsDermatitis, AtopicHumansImmunoglobulin EPrecision MedicineT-LymphocytesAllergensImmunoglobulin E

Identifiers

PMID28622169
PMCPMC6392175
OpenAlexW2626373306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.