ArticleGut microbes2017
Loop ileostomy-mediated fecal stream diversion is associated with microbial dysbiosis.
Article in Gut microbes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05905393 (The Protective Role of Preoperative Stimulation of the Distal Limb of the Ileostomy Loop With GABA Before Ileostomy Closure), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Protective Role of Preoperative Stimulation of the Distal Limb of the Ileostomy Loop With GABA Before Ileostomy Closure
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Efferent limb stimulation prior to loop ileostomy closure: a systematic review and meta-analysis.Techniques in coloproctology · 2023Pooled it
- Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis.Techniques in coloproctology · 2021Pooled it
- Bowel Stimulation Before Loop Ileostomy Closure Using Probiotics: Study Protocol for a Randomized Controlled Trial at a Single Center.JMIR research protocols · 2026Trial
- Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics.Biomolecules · 2021Trial
- Trial
- Delayed Loop Ileostomy Reversal Increases the Risk of Colitis and Clostridium difficile Infection.ANZ journal of surgery · 2026Article
- Risk factors for infectious enteritis after temporary stoma closure following colorectal cancer surgery: a retrospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Ileostoma as a promising tool in pathophysiological study and clinical intervention: a review from bench to beside.Frontiers in immunology · 2026Review
- Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy.Microbiology spectrum · 2025Article
- The Diagnosis and Evolution of Patients with LARS Syndrome: A Five-Year Retrospective Study from a Single Surgery Unit.Cancers · 2024Article
- Long-Term Functional Outcome After Early vs. Late Stoma Closure in Rectal Cancer Surgery: Sub-analysis of the Multicenter FORCE Trial.Journal of gastrointestinal cancer · 2024Article
- The impact of delayed closure of ileostomy on postoperative complications in patients with Crohn's disease: a case-matched study.Updates in surgery · 2024Article
- Successful allogeneic fecal microbiota transplantation for severe diversion colitis: a case report.The Journal of international medical research · 2024Article
- The impact of faecal diversion on the gut microbiome: a systematic review.Gut microbiome (Cambridge, England) · 2024Review
- Comparison of proactive and conventional treatment of anastomotic leakage in rectal cancer surgery: a multicentre retrospective cohort series.Techniques in coloproctology · 2023Article
- Dysbiosis of gut microbiota during fecal stream diversion in patients with colorectal cancer.Gut pathogens · 2023Article
- Management of Low Anterior Resection Syndrome (LARS) Following Resection for Rectal Cancer.Cancers · 2023Review
- Can physiological stimulation prior to ileostomy closure reduce postoperative ileus? A prospective multicenter pilot study.Techniques in coloproctology · 2022Article
- The impact of prolonged delay to loop ileostomy closure on postoperative morbidity and hospital stay: A retrospective cohort study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Review
- Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn's Disease.Digestive diseases and sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loop ileostomy is an effective procedure to protect downstream intestinal anastomoses. Ileostomy reversal surgery is often performed within 12 months of formation but is associated with substantial morbidity due to severe post-surgical complications. Distal ileum is deprived of enteral nutrition and rendered inactive, often becoming atrophied and fibrotic. This study aimed to investigate the microbial and morphological changes that occur in the defunctioned ileum following loop ileostomy-mediated fecal stream diversion. Functional and defunctioned ileal resection tissue was obtained at the time of loop-ileostomy closure. Intrapatient comparisons, including histological assessment of morphology and epithelial cell proliferation, were performed on paired samples using the functional limb as control. Mucosal-associated microflora was quantified via determination of 16S rRNA gene copy number using qPCR analysis. DGGE with Sanger sequencing and qPCR methods profiled microflora to genus and phylum level, respectively. Reduced villous height and proliferation confirmed atrophy of the defunctioned ileum. DGGE analysis revealed that the microflora within defunctioned ileum is less diverse and convergence between defunctioned microbiota profiles was observed. Candidate Genera, notably Clostridia and Streptococcus, reduced in relative terms in defunctioned ileum. We conclude that Ileostomy-associated nutrient deprivation results in dysbiosis and impaired intestinal renewal in the defunctioned ileum. Altered host-microbial interactions at the mucosal surface likely contribute to the deterioration in homeostasis and thus may underpin numerous postoperative complications. Strategies to sustain the microflora before reanastomosis should be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.