Evidence map›Paper›PMID 28621910›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018

Allospecific Memory B Cell Responses Are Dependent on Autophagy.

M Fribourg, J Ni, F Nina Papavasiliou, Z Yue, P S Heeger, J S Leventhal

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Inflammasomes and autophagy in cancer: unlocking targeted therapies.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  2. Review
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  4. Review
  5. Article
  6. Article
  7. C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

M FribourgDepartment of Neurology and Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai, New York, NY.
J NiDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
F Nina PapavasiliouDepartment of Immunology, Virology and Microbiology, The Rockefeller University, New York, NY.
Z YueDepartment of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
P S HeegerDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
J S LeventhalDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Icahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · USJames J. Peters VA Medical Center · USRockefeller University · US

Funding

Project I: Immunity to Influenza in Primary Lung Epithelial CellsU19AI117873 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAYOT, FERNAND · 2015 to 2019
$8.6M
Translational Immunology Training ProgramT32AI078892 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum, SERGIO A. LIRA · 2008 to 2026
$4.5M
Complement & T Cell Medicated Allograft RejectionR01AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2007 to 2016
$4.3M
The Role of Autophagy in LPS-Induced Acute Kidney InjuryK08DK090217 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEVENTHAL, JEREMY SETH · 2013 to 2017
$755k
NIAID NIH HHS R01 AI071185NIAID NIH HHS T32 AI078892NIAID NIH HHS U19 AI117873NIDDK NIH HHS K08 DK090217
6 · The paper itself

Abstract

Long-lived, donor-reactive memory B cells (Bmems) can produce alloantibodies that mediate transplant injury. Autophagy, an intrinsic mechanism of cell organelle/component recycling, is required for Bmem survival in infectious and model antigen systems, but whether autophagy affects alloreactive Bmem is unknown. We studied mice with an inducible yellow fluorescent protein (YFP) reporter expressed under the activation-induced cytidine deaminase (AID) promoter active in B cells undergoing germinal center reactions. Up to 12 months after allogeneic sensitization, splenic YFP

Indexed as

AutophagyHeart TransplantationAdenineAnimalsAntibodies, MonoclonalAutophagy-Related Protein 7B-LymphocytesImmunologic MemoryIsoantibodiesLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLTransplantation, Homologous3-methyladenineAdenineAntibodies, MonoclonalAtg7 protein, mouseAutophagy-Related Protein 7Isoantibodiesalloantibodyalloantigenbasic (laboratory) research/scienceB cell biologycellular biologydesensitizationheart transplantation/cardiologyimmunobiologyrejection: antibody-mediated (ABMR)

Identifiers

PMID28621910
PMCPMC5732898
OpenAlexW2626208522

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.