ArticleeLife2017
Neural mechanisms of social learning in the female mouse.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Distinct Modulation ofeNeuro · 2024Article
- Activation of arginine vasopressin receptor 1a reduces inhibitory synaptic currents at reciprocal synapses in the mouse accessory olfactory bulb.Frontiers in cellular neuroscience · 2024Article
- Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of Social Chemosignals in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- The Bruce effect: Representational stability and memory formation in the accessory olfactory bulb of the female mouse.Cell reports · 2022Article
- Cupid's quiver: Integrating sensory cues in rodent mating systems.Frontiers in neural circuits · 2022Review
- Review
- Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Operant conditioning of motor cortex neurons reveals neuron-subtype-specific responses in a brain-machine interface task.Scientific reports · 2020Article
- Paradoxically Sparse Chemosensory Tuning in Broadly Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Repeated Paced Mating Increases the Survival of New Neurons in the Accessory Olfactory Bulb.Frontiers in neuroscience · 2020Article
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- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- αLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Genetic tagging of active neurons in auditory cortex reveals maternal plasticity of coding ultrasonic vocalizations.Nature communications · 2018Article
- Functional Plasticity of Odor Representations during Motherhood.Cell reports · 2017Article
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- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Social interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones of the stud male that alters neuroendocrine responses to his chemosignals for many weeks. The cellular and synaptic correlates of pheromonal learning, however, remain unclear. We examined local circuit changes in the accessory olfactory bulb (AOB) using targeted ex vivo recordings of mating-activated neurons tagged with a fluorescent reporter. Imprinting led to striking plasticity in the intrinsic membrane excitability of projection neurons (mitral cells, MCs) that dramatically curtailed their responsiveness, suggesting a novel cellular substrate for pheromonal learning. Plasticity was selectively expressed in the MC ensembles activated by the stud male, consistent with formation of memories for specific individuals. Finally, MC excitability gained atypical activity-dependence whose slow dynamics strongly attenuated firing on timescales of several minutes. This unusual form of AOB plasticity may act to filter sustained or repetitive sensory signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.