ArticleInternational journal of oral science2017
Marginal bone loss around non-submerged implants is associated with salivary microbiome during bone healing.
Article in International journal of oral science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Impact of bisphosphonate drugs on dental implant healing and peri-implant hard and soft tissues: a systematic review.BMC oral health · 2022Pooled it
- Peri-implant marginal bone topography at the uncover stage: a classification proposal and retrospective observational study.International journal of implant dentistry · 2026Observational
- Thread design optimization of a dental implant using explicit dynamics finite element analysis.Scientific reports · 2025Article
- Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming.Bioactive materials · 2025Article
- Saliva biofilm-derived outer membrane vesicles regulate biofilm formation and immune response of oral epithelial cells on titanium surfaces.Clinical oral investigations · 2024Article
- Exploring links between oral health and infective endocarditis.Frontiers in oral health · 2024Review
- Clinical outcome of narrow diameter dental implants: a 3-year retrospective study.Maxillofacial plastic and reconstructive surgery · 2023Article
- Guidance and rationale for the immediate implant placement in the maxillary molar.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2023Article
- Oral Microbiota Alteration and Roles in Epstein-Barr Virus Reactivation in Nasopharyngeal Carcinoma.Microbiology spectrum · 2023Article
- Marginal Bone Loss around Implant-Retaining Overdentures versus Implant-Supported Fixed Prostheses 12-Month Follow-Up: A Retrospective Study.International journal of environmental research and public health · 2022Article
- Management of systemic risk factors ahead of dental implant therapy: A beard well lathered is half shaved.Journal of leukocyte biology · 2021Review
- Comparing the nasal bacterial microbiome diversity of allergic rhinitis, chronic rhinosinusitis and control subjects.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Trabeculae microstructure parameters serve as effective predictors for marginal bone loss of dental implant in the mandible.Scientific reports · 2020Article
- Salivary microbiome in patients undergoing hemodialysis and its associations with the duration of the dialysis.BMC nephrology · 2020Article
- Clinical Performance of Short Expandable Dental Implants for Oral Rehabilitation in Highly Atrophic Alveolar Bone: 3-year Results of a Prospective Single-Center Cohort Study.Medicina (Kaunas, Lithuania) · 2020Article
- Dual Delivery of Alendronate and E7-BMP-2 Peptide via Calcium Chelation to Mineralized Nanofiber Fragments for Alveolar Bone Regeneration.ACS biomaterials science & engineering · 2020Article
- Microbiota in Human Periodontal Abscess Revealed by 16S rDNA Sequencing.Frontiers in microbiology · 2019Article
- Review
- Microbiome and the inflammatory pathway in peri-implant health and disease with an updated review on treatment strategies.Journal of oral biology and craniofacial researchReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marginal bone loss during bone healing exists around non-submerged dental implants. The aim of this study was to identify the relationship between different degrees of marginal bone loss during bone healing and the salivary microbiome. One hundred patients were recruited, and marginal bone loss around their implants was measured using cone beam computed tomography during a 3-month healing period. The patients were divided into three groups according to the severity of marginal bone loss. Saliva samples were collected from all subjected and were analysed using 16S MiSeq sequencing. Although the overall structure of the microbial community was not dramatically altered, the relative abundance of several taxonomic groups noticeably changed. The abundance of species in the phyla Spirochaeta and Synergistetes increased significantly as the bone loss became more severe. Species within the genus Treponema also exhibited increased abundance, whereas Veillonella, Haemophilus and Leptotrichia exhibited reduced abundances, in groups with more bone loss. Porphyromonasgingivalis, Treponemadenticola and Streptococcus intermedius were significantly more abundant in the moderate group and/or severe group. The severity of marginal bone loss around the non-submerged implant was associated with dissimilar taxonomic compositions. An increased severity of marginal bone loss was related to increased proportions of periodontal pathogenic species. These data suggest a potential role of microbes in the progression of marginal bone loss during bone healing.
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Registered trials
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