ArticleInternational journal of oral science2017
A robust methodology for the quantitative assessment of the rat jawbone microstructure.
Article in International journal of oral science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Challenges and limitations in developing of a new maxillary standardized rat alveolar bone defect model to study bone regenerative approaches in oral and maxillofacial surgery.Frontiers in bioengineering and biotechnology · 2025Article
- Definition of the Region of Interest for the Assessment of Alveolar Bone Repair Using Micro-computed Tomography.Journal of digital imaging · 2023Article
- Significance of medication discontinuation on bisphosphonate-related jaw osteonecrosis in a rat model.Scientific reports · 2022Article
- Dynamic changes in tooth displacement and bone morphometry induced by orthodontic force.Scientific reports · 2022Article
- X-ray computed microtomography datasets for osteogenic nanofibrous coated titanium implants.Scientific data · 2022Article
- Optimal Parameters of Laser Therapy to Improve Critical Calvarial Defects.Frontiers in physiology · 2022Article
- Micro-CT-Based Bone Microarchitecture Analysis of the Murine Skull.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Effect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo.Drug design, development and therapy · 2022Article
- Refining the mandibular osteoradionecrosis rat model by in vivo longitudinal µCT analysis.Scientific reports · 2021Article
- Is the Jaw Bone Micro-Structure Altered in Response to Osteoporosis and Bisphosphonate Treatment? A Micro-CT Analysis.International journal of molecular sciences · 2021Article
- Review
- Caprine demineralized bone matrix (DBMc) in the repair of non-critical bone defects in rabbit tibias. A new bone xenograft.Acta cirurgica brasileira · 2020Article
- Effects of pentoxifylline and tocopherol on a rat-irradiated jaw model using micro-CT cortical bone analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro-computed tomography can be applied for the assessment of the micro-architectural characteristics of the cortical and trabecular bones in either physiological or disease conditions. However, reports often lack a detailed description of the methodological steps used to analyse these images, such as the volumes of interest, the algorithms used for image filtration, the approach used for image segmentation, and the bone parameters quantified, thereby making it difficult to compare or reproduce the studies. This study addresses this critical need and aims to provide standardized assessment and consistent parameter reporting related to quantitative jawbone image analysis. Various regions of the rat jawbones were screened for their potential for standardized micro-computed tomography analysis. Furthermore, the volumes of interest that were anticipated to be most susceptible to bone structural changes in response to experimental interventions were defined. In the mandible, two volumes of interest were selected, namely, the condyle and the trabecular bone surrounding the three molars. In the maxilla, the maxillary tuberosity region and the inter-radicular septum of the second molar were considered as volumes of interest. The presented protocol provides a standardized and reproducible methodology for the analysis of relevant jawbone volumes of interest and is intended to ensure global, accurate, and consistent reporting of its morphometry. Furthermore, the proposed methodology has potential, as a variety of rodent animal models would benefit from its implementation.
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