Trial reportJournal of clinical periodontology2017
Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial.
Trial report in Journal of clinical periodontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review.Oral diseases · 2025Pooled it
- Effect of periodontal treatments on blood pressure.The Cochrane database of systematic reviews · 2021Pooled it
- Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial.Journal of clinical periodontology · 2017Trial
- Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment.Scandinavian journal of immunology · 2026Article
- Relationship between periodontitis and systemic health conditions: a narrative review.Ewha medical journal · 2025Review
- Association of periodontitis with cardiometabolic and haemostatic parameters.Clinical oral investigations · 2024Article
- Impact of dental health intervention on cardiovascular metabolic risk: a pilot study of Japanese adults.Journal of human hypertension · 2024Article
- Impact of Nonsurgical Periodontal Treatment on Blood Pressure: A Prospective Cohort Study.European journal of dentistry · 2024Article
- Metabolic Conditions and Peri-Implantitis.Antibiotics (Basel, Switzerland) · 2022Review
- Does Periodontal Treatment Help in Arterial Hypertension Control? A Systematic Review of Literature.European journal of dentistry · 2021Article
- Periodontal therapy increases neutrophil extracellular trap degradation.Innate immunity · 2020Article
- Neutrophil Extracellular Traps in Periodontitis.Cells · 2020Review
- Reporting quality and spin in abstracts of randomized clinical trials of periodontal therapy and cardiovascular disease outcomes.PloS one · 2020Article
- The link between periodontitis and erectile dysfunction: a review.British dental journal · 2019Review
- Markers, Pathways, and Current Evidence for Periodontitis-associated Insulin Resistance: A Narrative Review.Journal of International Society of Preventive & Community DentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL-cholesterol, triglycerides, glucose).
methodsOne hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post-therapy. Number of patients with undiagnosed MetS was also determined.
resultsIn all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post-therapy, systolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow-up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self-reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12-month follow-up (p = .383).
conclusionAlthough a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.
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Registered trials
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