ArticleJournal of medical primatology2018
Diet-induced early-stage atherosclerosis in baboons: Lipoproteins, atherogenesis, and arterial compliance.
Article in Journal of medical primatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- [EJNMMI research · 2026Article
- A Reassessment of the Genomic Ancestry of the World's Largest Captive Baboon Colony.American journal of primatology · 2025Article
- Tracking Molar Wear in Captive Baboons: Sex and Age Effects Using a Modified Scott Scoring System.American journal of biological anthropology · 2025Article
- Non-rodent Models of Atherosclerosis: Repurposing of Existing Drugs and Search for Novel Treatment Strategies.Current cardiology reviews · 2025Review
- Article
- Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons.Cell genomics · 2024Article
- Potential miRNA biomarkers and therapeutic targets for early atherosclerotic lesions.Scientific reports · 2023Article
- Maternal obesity alters offspring liver and skeletal muscle metabolism in early post-puberty despite maintaining a normal post-weaning dietary lifestyle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Hepatic transcript signatures predict atherosclerotic lesion burden prior to a 2-year high cholesterol, high fat diet challenge.PloS one · 2022Article
- Research methodology for in vivo measurements of resting energy expenditure, daily body temperature, metabolic heat and non-viral tissue-specific gene therapy in baboons.Research in veterinary science · 2020Article
- Histological variation of early stage atherosclerotic lesions in baboons after prolonged challenge with high-cholesterol, high-fat diet.Journal of medical primatology · 2020Article
- Diet-induced leukocyte telomere shortening in a baboon model for early stage atherosclerosis.Scientific reports · 2019Article
- Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony.Genome research · 2019Article
- A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta.Journal of medical primatology · 2019Article
- Identification of coordinately regulated microRNA-gene networks that differ in baboons discordant for LDL-cholesterol.PloS one · 2019Article
- Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis.PloS one · 2019Article
- Restricted MHC class I A locus diversity in olive and hybrid olive/yellow baboons from the Southwest National Primate Research Center.Immunogenetics · 2018Article
- Nonhuman Primates and Translational Research-Cardiovascular Disease.ILAR journal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe purpose of this study was to determine whether dietary manipulation can reliably induce early-stage atherosclerosis and clinically relevant changes in vascular function in an established, well-characterized non-human primate model.
methodsWe fed 112 baboons a high-cholesterol, high-fat challenge diet for two years. We assayed circulating biomarkers of cardiovascular disease (CVD) risk, at 0, 7, and 104 weeks into the challenge; assessed arterial compliance noninvasively at 104 weeks; and measured atherosclerotic lesions in three major arteries at necropsy.
resultsWe observed evidence of atherosclerosis in all but one baboon fed the two-year challenge diet. CVD risk biomarkers, the prevalence, size, and complexity of arterial lesions, plus consequent arterial stiffness, were increased in comparison with dietary control animals.
conclusionsFeeding baboons a high-cholesterol, high-fat diet for two years reliably induces atherosclerosis, with risk factor profiles, arterial lesions, and changes in vascular function also seen in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.