ArticleInternal and emergency medicine2017
Quality of life impairment in Behçet's disease and relationship with disease activity: a prospective study.
Article in Internal and emergency medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 83 citations in OpenAlex.
- Impact of apremilast on quality of life in Behçet's syndrome: analysis of the phase 3 RELIEF study.RMD open · 2022Trial
- Visual prognosis of Behçet's uveitis patients in China and its associated factors.Frontiers in immunology · 2026Article
- Review
- Epidemiology and treatment of Adamantiades-Behçet's disease in Germany: A healthcare claims database study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Relation of Social Participation Restrictions with Worsening Quality of Life in Japanese Patients with Behçet's Disease: The 36-item Short Form Survey.JMA journal · 2025Article
- A 20-year real-world study on drug survival and predictive factors for infliximab discontinuation in Behçet's syndrome.Frontiers in immunology · 2025Article
- Thoughts and Experiences of Behçet Disease From Participants on a Reddit Subforum: Qualitative Online Community Analysis.JMIR formative research · 2023Article
- A patient-driven registry on Behçet's disease: the AIDA for patients pilot project.Frontiers in medicine · 2023Article
- Effects of anti-SARS-CoV-2 vaccination on safety and disease exacerbation in patients with Behçet syndrome in a monocentric cohort.International journal of rheumatic diseases · 2022Article
- Global systematic review and meta-analysis of health-related quality of life in Behcet's patients.Caspian journal of internal medicine · 2022Review
- Role of Adalimumab Biosimilar in the Treatment of Non-Anterior Uveitis Associated with Behçet's Syndrome.Ophthalmology and therapy · 2021Article
- Clinical profile and evolution of patients with juvenile-onset Behçet's syndrome over a 25-year period: insights from the AIDA network.Internal and emergency medicine · 2021Article
- Being a caregiver of a Behçet's syndrome patient: challenges and perspectives during a complex journey.Orphanet journal of rare diseases · 2021Article
- Behçet syndrome.Nature reviews. Disease primers · 2021Review
- Quality of life in neuro-Behçet's disease: a cross-sectional study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Cluster analysis of phenotypes of patients with Behçet's syndrome: a large cohort study from a referral center in China.Arthritis research & therapy · 2021Article
- The Efficacy of Adalimumab as an Initial Treatment in Patients with Behçet's Retinal Vasculitis.Frontiers in pharmacology · 2021Article
- Behçet's syndrome in Italy: a detailed retrospective analysis of 396 cases seen in 3 tertiary referral clinics.Internal and emergency medicine · 2020Article
- Quality of Life Assessment in Patients with Behçet's Disease using the Persian Version of the Leeds BD-QoL Questionnaire.Iranian journal of medical sciences · 2020Article
- Clinical features and management of venous thromboembolism in patients with Behçet's syndrome: a single-center case-control study.Internal and emergency medicine · 2020Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
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Abstract
Our aim was to prospectively investigate the impact of Behçet's disease (BD), disease activity, and clinical and demographic characteristics on different aspects of quality of life (QoL) measured by the short-form (SF)-36 QoL scale. We administered the SF-36 to 37 consecutive BD patients in different moments of disease activity, and to 23 healthy controls (HC). The eight subcategories of the SF-36 underwent statistical analysis for identifying differences and correlations. Compared to HC, BD patients showed significantly lower mean scores in all SF-36 QoL subscales except mental health and role-emotional. Females showed a poorer QoL compared to males. Disease activity evaluated by the BD Current Activity Form inversely correlated with physical functioning (ρ = -0.68, p < 0.0001), bodily pain (ρ = -0.68, p < 0.0001), role-physical (ρ = -0.64, p < 0.0001), vitality (ρ = -0.64, p < 0.0001), general health (ρ = -0.64, p < 0.0001), social functioning (ρ = -0.50, p = 0.0002), mental health (ρ = -0.48, p = 0.0004), and role-emotional (ρ = -0.40, p = 0.003). Mucosal, central nervous system (CNS), musculoskeletal and ocular manifestations were the main factors that negatively affected QoL in BD. For ocular disease, physical functioning was significantly impaired in patients with panuveitis compared to other ocular manifestations (p = 0.0002). Best-corrected visual acuity was inversely correlated with social functioning (ρ = -0.53, p < 0.0001), role-physical (ρ = -0.48, p < 0.0001), bodily pain (ρ = -0.46, p = 0.02), and mental health (ρ = -0.43, p < 0.0001). Patients with BD have a poorer QoL compared to HC, particularly for women, while the decline of QoL is closely related to the overall disease activity of BD. Single organ involvements may affect independently specific SF-36 subscales, especially mucosal, CNS, musculoskeletal, and ocular manifestations.
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