ReviewCurrent treatment options in cardiovascular medicine2017
Advanced Neuroimaging of Cerebral Small Vessel Disease.
Review in Current treatment options in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Contrasting patterns of leptomeningeal and parenchymal gadolinium extravasation in cerebral amyloid angiopathy: An MRI-based evaluation.International journal of stroke : official journal of the International Stroke Society · 2026Article
- The association between obstructive sleep apnea and total cerebral small vessel disease burden-Neurovascular insights of OSA.Frontiers in neuroscience · 2026Article
- Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury.Journal of cachexia, sarcopenia and muscle · 2025Article
- Endothelial cells as key players in cerebral small vessel disease.Nature reviews. Neuroscience · 2025Review
- Review
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages.GeroScience · 2024Review
- Assessment of arterial pulsatility of cerebral perforating arteries using 7T high-resolution dual-VENC phase-contrast MRI.Magnetic resonance in medicine · 2024Article
- Vessel density mapping of small cerebral vessels on 3D high resolution black blood MRI.NeuroImage · 2024Article
- Serum vascular endothelial growth factor and cortisol expression to predict prognosis of patients with hypertensive cerebral hemorrhage.World journal of clinical cases · 2023Article
- New horizons in cognitive and functional impairment as a consequence of cerebral small vessel disease.Age and ageing · 2023Article
- Decreased water exchange rate across blood-brain barrier in hereditary cerebral small vessel disease.Brain : a journal of neurology · 2023Article
- Audiological Diagnosis of Valvular and Congenital Heart Diseases in the Era of Artificial Intelligence.Reviews in cardiovascular medicine · 2023Review
- Advanced MRI in cerebral small vessel disease.International journal of stroke : official journal of the International Stroke Society · 2023Review
- The microstructural abnormalities of cingulum was related to patients with mild cognitive impairment: a diffusion kurtosis imaging study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Structural retinal changes in cerebral small vessel disease.Scientific reports · 2022Article
- Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Rare Neurovascular Diseases in Korea: Classification and Related Genetic Variants.Korean journal of radiology · 2021Review
- Multi-Dimensional Diffusion Tensor Imaging Biomarkers for Cognitive Decline From the Preclinical Stage: A Study of Post-stroke Small Vessel Disease.Frontiers in neurology · 2021Article
- Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project.Cerebral circulation - cognition and behavior · 2021Article
- Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI.Journal of magnetic resonance imaging : JMRI · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
opinion statementCerebral small vessel disease (SVD) is characterised by damage to deep grey and white matter structures of the brain and is responsible for a diverse range of clinical problems that include stroke and dementia. In this review, we describe advances in neuroimaging published since January 2015, mainly with magnetic resonance imaging (MRI), that, in general, are improving quantification, observation and investigation of SVD focussing on three areas: quantifying the total SVD burden, imaging brain microstructural integrity and imaging vascular malfunction. Methods to capture 'whole brain SVD burden' across the spectrum of SVD imaging changes will be useful for patient stratification in clinical trials, an approach that we are already testing. More sophisticated imaging measures of SVD microstructural damage are allowing the disease to be studied at earlier stages, will help identify specific factors that are important in development of overt SVD imaging features and in understanding why specific clinical consequences may occur. Imaging vascular function will help establish the precise blood vessel and blood flow alterations at early disease stages and, together with microstructural integrity measures, may provide important surrogate endpoints in clinical trials testing new interventions. Better knowledge of SVD pathophysiology will help identify new treatment targets, improve patient stratification and may in future increase efficiency of clinical trials through smaller sample sizes or shorter follow-up periods. However, most of these methods are not yet sufficiently mature to use with confidence in clinical trials, although rapid advances in the field suggest that reliable quantification of SVD lesion burden, tissue microstructural integrity and vascular dysfunction are imminent.
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