Evidence map›Paper›PMID 28620613›Full record

ArticleInternational journal of genomics2017

Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences.

Gregory C Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu and 5 more

Abstract read
In one paragraph

Article in International journal of genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gregory C AntellDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Will DampierDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-3362-2610
Benjamas AiamkitsumritDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-0255-7203
Michael R NonnemacherDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0003-4299-3779
Vanessa PirroneDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-4922-8503
Wen ZhongDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Katherine KercherDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Shendra PassicDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Jean WilliamsDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Yucheng LiuDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Tony JamesDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
Jeffrey M JacobsonCenter for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA.
Zsofia SzepCenter for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA, USA.
Brian WigdahlDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-5211-0936
Fred C KrebsDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1530-4432

Funding

Viral Gene Editing and Bioinformatics Core for Institution # 269291P30MH092177 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI SHOHREH AMINI · 2011 to 2026
$24.9M
Interdisciplinary And Translational Research Training In NeurohivT32MH079785 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI Kamel Khalili · 2008 to 2026
$5.4M
High Specificity HIV-1 Markers Predictive of Neuro-AIDSR01DA019807 · NIDA · DREXEL UNIVERSITY · PI WIGDAHL, BRIAN · 2004 to 2014
$5.1M
HIV-1 Tat genetic variation impacts NeuroAIDSR01NS089435 · NINDS · DREXEL UNIVERSITY · PI KORTAGERE, SANDHYA, NONNEMACHER, MICHAEL R · 2015 to 2024
$5.0M
NEUROLOGICAL &LYMPHOID FACTORS IN HIV1 LTR ACTIVATIONR01NS032092 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WIGDAHL, BRIAN · 1993 to 2011
$3.9M
Co-evolution of HIV-1 Regulators in CNS DiseaseR01NS046263 · NINDS · DREXEL UNIVERSITY · PI WIGDAHL, BRIAN · 2004 to 2009
$1.8M
NIDA NIH HHS R01 DA019807NIMH NIH HHS P30 MH092177NIMH NIH HHS T32 MH079785NINDS NIH HHS R01 NS032092NINDS NIH HHS R01 NS046263NINDS NIH HHS R01 NS089435
6 · The paper itself

Abstract

Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis that HIV-1 tropism extends beyond the envelope into the

Identifiers

PMID28620613
PMCPMC5460428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.