ArticleFertility research and practice2017
Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.
Article in Fertility research and practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Mean platelet volume and polycystic ovary syndrome: a systematic review and meta-analysis.The Journal of international medical research · 2022Pooled it
- The association between the follicular distribution pattern of polycystic ovaries and metabolic syndrome development in patients with polycystic ovary syndrome a prospective cohort study.Scientific reports · 2025Article
- Ovarian Morphology in Girls Longitudinal Cohort Study: Pilot Evaluation of Ovarian Morphology as a Biomarker of Reproductive and Metabolic Features during the First Gynecological Year.Journal of pediatric and adolescent gynecology · 2024Article
- Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review).Biomedical reports · 2024Review
- Ovarian volume is more closely related to the different manifestations of polycystic ovary syndrome than follicle number per ovary.Clinical and experimental reproductive medicine · 2023Article
- Diagnostic Performance of Ovarian Morphology on Ultrasonography across Anovulatory Conditions-Impact of Body Mass Index.Diagnostics (Basel, Switzerland) · 2023Article
- The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review.Metabolites · 2023Review
- Ovarian volume as an independent marker for metabolic dysfunction in women with suspected androgen excess.F&S reports · 2022Article
- Ovarian volume, not follicle count, is independently associated with androgens in patients with polycystic ovary syndrome.BMC endocrine disorders · 2022Article
- Correlation of Clinical, Hormonal, Biochemical and Ultrasound Parameters Between Adult and Adolescent Polycystic Ovarian Syndrome: Adult and Adolescent PCOS.Journal of obstetrics and gynaecology of India · 2022Article
- A Cross-Sectional Study on Potential Ovarian Volume and Related Factors in Women with Polycystic Ovary Syndrome from Infertile Couples.International journal of women's health · 2021Article
- Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto's Thyroiditis: How Far Is Our Understanding?Frontiers in immunology · 2021Review
- Ovarian volume is associated with adiposity measures and bone mineral density in postmenopausal women.Journal of musculoskeletal & neuronal interactions · 2018Article
- Is there a Relationship between Serum IGF-1 and Thyroid Nodule, Thyroid or Ovarian Volume in Polycystic Ovarian Syndrome?Acta endocrinologica (Bucharest, Romania : 2005)Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPolycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk.
methodsThis is a cross-sectional study of patients seen in a multidisciplinary PCOS clinic at the University of California at San Francisco between 2006 and 2014. All participants underwent systematic evaluation with anthropometric measurements, comprehensive skin exam, transvaginal ultrasound and laboratory studies at the time of their initial visit to the clinic. Serum samples were stored and androgen studies were carried out on all stored samples at the University of Virginia. Logistic regression was employed to evaluate the association between ovarian volume or follicle number and metabolic parameters (fasting insulin, HOMA-IR, fasting glucose, 2 h glucose, waist circumference) and hyperandrogenism (free testosterone, total testosterone, DHEAS, acanthosis nigricans), controlling for age.
resultsThree-hundred thirteen patients seen during the study period met Rotterdam criteria for PCOS and had sufficient measurements for inclusion in our analysis. The odds ratio of elevated HOMA-IR for patients with a maximum ovarian volume >10 cc was 1.9 compared to those with a maximum ovarian volume of ≤10 cc (95% CI 1.0-3.4). The odds ratio of abnormal fasting insulin for patients with higher ovarian volume was 1.8 (95% CI 1.0-3.4) compared with those with lower ovarian volume. Follicle number was not significantly associated with any metabolic parameters.
conclusionsIncreased ovarian volume is associated with markers of insulin resistance in PCOS. In concordance with prior studies, we did not find follicle number to be predictive of metabolic risk. Ovarian volume may serve as a useful tool to aid clinicians in their risk stratification and counseling of patients with PCOS.
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