ArticleEndocrinology, diabetes & metabolism case reports2017
Growth hormone and insulin-like growth factor 1 affect the severity of Graves' disease.
Article in Endocrinology, diabetes & metabolism case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Development of Marine-Lenhart Syndrome during the Course of Acromegaly.Internal medicine (Tokyo, Japan) · 2026Article
- Growth hormone-secreting pituitary adenoma combined with Graves' disease: retrospective case series and literature review.Endocrine connections · 2024Article
- A rare form of hyperthyroidism leading to the diagnosis of acromegaly: A case report.Experimental and therapeutic medicine · 2023Article
- Association of an empty sella and grave´s disease in a patient with acromegaly: a case report.The Pan African medical journal · 2021Article
- Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graves' disease, the most common form of hyperthyroidism in iodine-replete countries, is associated with the presence of immunoglobulins G (IgGs) that are responsible for thyroid growth and hyperfunction. In this article, we report the unusual case of a patient with acromegaly and a severe form of Graves' disease. Here, we address the issue concerning the role of growth hormone (GH) and insulin-like growth factor 1 (IGF1) in influencing thyroid function. Severity of Graves' disease is exacerbated by coexistent acromegaly and both activity indexes and symptoms and signs of Graves' disease improve after the surgical remission of acromegaly. We also discuss by which signaling pathways GH and IGF1 may play an integrating role in regulating the function of the immune system in Graves' disease and synergize the stimulatory activity of Graves' IgGs. LEARNING POINTS: Clinical observations have demonstrated an increased prevalence of euthyroid and hyperthyroid goiters in patients with acromegaly.The coexistence of acromegaly and Graves' disease is a very unusual event, the prevalence being <1%.Previous
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