ReviewF1000Research2017
Recent insights on principles of synaptic protein degradation.
Review in F1000Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Ketamine preserves perineuronal nets in chronic stressed mice brain through the inhibition of microglia activation.IBRO neuroscience reports · 2026Article
- Synaptojanin1 regulates synaptic dopamine release and axonal integrity via retromer-dependent endosomal sorting.Research square · 2026Article
- Autophagy in alzheimer disease pathogenesis and its therapeutic values.Autophagy reports · 2025Review
- Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1bioRxiv : the preprint server for biology · 2023Article
- Article
- [Effects of ring finger and tryptophan-aspartic acid 2 on dendritic spines and synapse formation in cerebral cortex neurons of mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Organization of Presynaptic Autophagy-Related Processes.Frontiers in synaptic neuroscience · 2022Review
- Regulation of neuronal autophagy and the implications in neurodegenerative diseases.Neurobiology of disease · 2022Review
- PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.Science translational medicine · 2021Article
- Autophagy and the endolysosomal system in presynaptic function.Cellular and molecular life sciences : CMLS · 2021Review
- Bassoon inhibits proteasome activity via interaction with PSMB4.Cellular and molecular life sciences : CMLS · 2021Article
- From Metabolic Syndrome to Neurological Diseases: Role of Autophagy.Frontiers in cell and developmental biology · 2021Review
- CBeLife · 2020Article
- Neuronal Autophagy in Synaptic Functions and Psychiatric Disorders.Biological psychiatry · 2020Review
- Review
- Emerging Concepts and Functions of Autophagy as a Regulator of Synaptic Components and Plasticity.Cells · 2019Review
- Article
- The where, what, and when of membrane protein degradation in neurons.Developmental neurobiology · 2018Review
- NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model.Frontiers in cellular neuroscience · 2018Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintaining synaptic integrity and function depends on the continuous removal and degradation of aged or damaged proteins. Synaptic protein degradation has received considerable attention in the context of synaptic plasticity and growing interest in relation to neurodegenerative and other disorders. Conversely, less attention has been given to constitutive, ongoing synaptic protein degradation and the roles canonical degradation pathways play in these processes. Here we briefly review recent progress on this topic and new experimental approaches which have expedited such progress and highlight several emerging principles. These include the realization that synaptic proteins typically have unusually long lifetimes, as might be expected from the remote locations of most synaptic sites; the possibility that degradation pathways can change with time from synthesis, cellular context, and physiological input; and that degradation pathways, other than ubiquitin-proteasomal-mediated degradation, might play key roles in constitutive protein degradation at synaptic sites. Finally, we point to the importance of careful experimental design and sufficiently sensitive techniques for studying synaptic protein degradation, which bring into account their slow turnover rates and complex life cycles.
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Registered trials
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