Evidence map›Paper›PMID 28620445›Full record

ArticleThe EPMA journal2017

Unusual gastrointestinal and cutaneous toxicities by bleomycin, etoposide, and cisplatin: a case report with pharmacogenetic analysis to personalize treatment.

Marzia Del Re, Tiziana Latiano, Leonardo Fidilio, Giuliana Restante, Franco Morelli, Evaristo Maiello, Romano Danesi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EPMA journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Hand-Foot Syndrome as a Rare Side Effect of Bleomycin.Pakistan journal of medical sciences · 2026
    Article
  2. Bilateral macular ischemia following oral etoposide.Indian journal of ophthalmology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marzia Del Re *Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 55, Via Roma, 56126 Pisa, Italy.
Tiziana Latiano *Medical Oncology Unit, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Foggia Italy.
Leonardo FidilioClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 55, Via Roma, 56126 Pisa, Italy.
Giuliana RestanteClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 55, Via Roma, 56126 Pisa, Italy.
Franco MorelliMedical Oncology Unit, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Foggia Italy.
Evaristo MaielloMedical Oncology Unit, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Foggia Italy.
Romano DanesiClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 55, Via Roma, 56126 Pisa, Italy.
University of Pisa · ITCasa Sollievo della Sofferenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The standard treatment of testicular germ cell tumors is based on the combination of bleomycin, etoposide, and cisplatin (PEB). However, this treatment may be associated with severe adverse reactions, such as hematological and non-hematological toxicities. Here, we report a case of a patient suffering from severe PEB-related toxicities, to whom pharmacogenetic analyses were performed, comprising a panel of genes involved in PEB metabolism. The analysis revealed the presence of a complex pattern of polymorphisms in

Indexed as

Bleomycin-etoposide-cisplatin combined treatmentPharmacogeneticsPolymorphismsPrecision medicinePredictive preventive personalized medicineTesticular germ cell cancerToxicity

Identifiers

PMID28620445
PMCPMC5471801
OpenAlexW2593444909

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.