Evidence map›Paper›PMID 28620379›Full record

ReviewFrontiers in immunology2017

Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor.

Fabiana Maria das Graças Corsi-Zuelli, Fernanda Brognara, Gustavo Fernando da Silva Quirino, Carlos Hiroji Hiroki, Rafael Sobrano Fais, Cristina Marta Del-Ben, Luis Ulloa, Helio Cesar Salgado, Alexandre Kanashiro, Camila Marcelino Loureiro

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
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  6. Review
  7. Review
  8. Oxidative Stress in Brain Function.Antioxidants (Basel, Switzerland) · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.Annals of depression and anxiety · 2023
    Article
  16. Review
  17. A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Fabiana Maria das Graças Corsi-ZuelliDepartment of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Fernanda BrognaraDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Gustavo Fernando da Silva QuirinoDepartment of Cellular and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Carlos Hiroji HirokiDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Rafael Sobrano FaisDepartment of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Cristina Marta Del-BenDepartment of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Luis UlloaDepartment of Surgery, Center of Immunology and Inflammation, Rutgers University-New Jersey Medical School, Newark, NJ, United States.
Helio Cesar SalgadoDepartment of Physiology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Alexandre KanashiroDepartment of Physiological Sciences, Federal University of São Carlos, São Carlos, Brazil.
Camila Marcelino LoureiroDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRRutgers, The State University of New Jersey · USUniversidade Federal de São Carlos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is one of the most debilitating mental disorders and is aggravated by the lack of efficacious treatment. Although its etiology is unclear, epidemiological studies indicate that infection and inflammation during development induces behavioral, morphological, neurochemical, and cognitive impairments, increasing the risk of developing schizophrenia. The inflammatory hypothesis of schizophrenia is also supported by clinical studies demonstrating systemic inflammation and microglia activation in schizophrenic patients. Although elucidating the mechanism that induces this inflammatory profile remains a challenge, mounting evidence suggests that neuroimmune interactions may provide therapeutic advantages to control inflammation and hence schizophrenia. Recent studies have indicated that vagus nerve stimulation controls both peripheral and central inflammation

Indexed as

alpha-7 nicotinic acetylcholine receptorcholinergic anti-inflammatory pathwaycytokinesimmune systeminflammationmicrogliaschizophreniavagus nerve stimulation

Identifiers

PMID28620379
PMCPMC5449450
OpenAlexW2617374717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.