Evidence map›Paper›PMID 28620344›Full record

ArticleFrontiers in neurology2017

The Role of Osteopontin and Its Gene on Glucocorticoid Response in Myasthenia Gravis.

Yanchen Xie, Hai-Feng Li, Liang Sun, Linda L Kusner, Shuhui Wang, Yunxiao Meng, Xu Zhang, Yu Hong, Xiang Gao, Yao Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Myasthenia gravis: the future is here.The Journal of clinical investigation · 2024
    Review
  4. Review
  5. TheNeural regeneration research · 2021
    Review
  6. Article
  7. Understanding the burden of refractory myasthenia gravis.Therapeutic advances in neurological disorders · 2019
    Review
  8. Article
  9. Advances in autoimmune myasthenia gravis management.Expert review of neurotherapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanchen XieDepartment of Neurology, The George Washington University, Washington, DC, United States.
Hai-Feng LiDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Liang SunThe Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Linda L KusnerDepartment of Pharmacology, The George Washington University, Washington, DC, United States.
Shuhui WangDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Yunxiao MengDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China.
Xu ZhangDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Yu HongDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xiang GaoDepartment of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Yao LiDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Henry J KaminskiDepartment of Neurology, The George Washington University, Washington, DC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers that assess treatment response for patients with the autoimmune disorder, myasthenia gravis (MG), have not been evaluated to a significant extent. We hypothesized the pro-inflammatory cytokine, osteopontin (OPN), may be associated with variability of response to glucocorticoids (GCs) in patients with MG. A cohort of 250 MG patients treated with standardized protocol of GCs was recruited, and plasma OPN and polymorphisms of its gene, secreted phosphoprotein 1 (

Indexed as

glucocorticoidmyasthenia gravisosteopontinquantitative myasthenia gravis scoresecreted phosphoprotein 1

Identifiers

PMID28620344
PMCPMC5450020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.