ArticleFrontiers in pharmacology2017
Chemopreventive Activity of Honokiol against 7, 12 - Dimethylbenz[a]anthracene-Induced Mammary Cancer in Female Sprague Dawley Rats.
Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Evaluation of Anti-Tumorigenic Effects of Curcumin and Baicalein in 7,12-Dimethylbenz[a] Anthracene-Induced Mammary Gland Tumorigenesis in Wistar Rats.Journal of biochemical and molecular toxicology · 2026Article
- Liposomal honokiol attenuates dimethylhydrazine-induced colon carcinogenesis in rats through modulation of oxidative stress, inflammation, apoptosis, autophagy, and lipid metabolism pathways.Medical oncology (Northwood, London, England) · 2026Article
- Comparative Effect of African Walnut Oil and Docosahexaenoic Acid on Hematological and Oxidative Stress Markers of Female Wistar Rats With 7,12-Dimethylbenz[a]anthracene-Induced Breast Cancer.Food science & nutrition · 2026Article
- Investigating Vitamin DMolecular diversity · 2026Article
- Phytochemical Profiling by UHPLC-Q-TOF/MS and Chemopreventive Effect of Aqueous Extract ofMolecules (Basel, Switzerland) · 2024Article
- Exploring the Protective Effect against 7,12-Dimethylbenz[a]anthracene-Induced Breast Tumors of Palmitoylethanolamide.ACS pharmacology & translational science · 2024Article
- Article
- In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cancer Therapy.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Assessment of Wheat Germ Oil Role in the Prevention of Induced Breast Cancer in Rats.ACS omega · 2022Article
- Phytochemical Constituents and Ameliorative Effect of the Essential Oil fromMolecules (Basel, Switzerland) · 2022Article
- Lung cancer induced by Benzo(A)Pyrene: ChemoProtective effect of sinapic acid in swiss albino mice.Saudi journal of biological sciences · 2021Article
- Histopathological evaluation ofVeterinary world · 2021Article
- The Essential Oil ofMolecules (Basel, Switzerland) · 2020Article
- Review
- [Study on effect and mechanism of Honokiol enhancing tumor necrosis factor-related apoptosis inducing ligand against hepatocellular carcinoma HepG2 cells via activating JNK signaling pathway].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018Article
- Chemoprevention of LA7-Induced Mammary Tumor Growth by SM6Met, a Well-CharacterizedFrontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is a predominant cause of death in women across the globe. Chemoprevention by using natural, dietary or synthetic products has been appearing to be a fascinating approach to combat the growing burden of breast cancer. In the current study, we intended to explore the mechanisms of chemopreventive action of honokiol against 7, 12 - dimethylbenz[a]anthracene (DMBA)-induced mammary cancer in female Sprague Dawlely (SD) rats. We induced mammary cancer in SD rats by administering single dose of DMBA (80 mg/kg) through intra gastric route. Chemopreventive effects of honokiol (80 mg/kg, i.p.) were confirmed from its ameliorating effect on the DMBA-induced anomalies such as liver marker enzymes, Phases I and II metabolizing enzymes and oxidative stress markers. Further, honokiol reversed the DMBA-induced abnormalities in inflammatory cytokines levels and serum tumor markers. Additionally, histopathological examination of mammary tissue and protein expression analysis of NF-κB revealed that honokiol is effective against DMBA-induced mammary cancer. In summary, the results of our study support the chemopreventive feature of honokiol in mammary cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.