ArticleFrontiers in aging neuroscience2017
Racial Differences in Insular Connectivity and Thickness and Related Cognitive Impairment in Hypertension.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Demographic reporting across a decade of neuroimaging: a systematic review.Brain imaging and behavior · 2022Pooled it
- Multivariate whole brain neurodegenerative-cognitive-clinical severity mapping in the Alzheimer's disease continuum using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dysregulated Salience Network Control over Default-Mode and Central-Executive Networks in Schizophrenia Revealed Using Stochastic Dynamical Causal Modeling.Brain connectivity · 2024Article
- Predicting cognitive dysfunction and regional hubs using Braak staging amyloid-beta biomarkers and machine learning.Brain informatics · 2023Article
- Alterations in regional homogeneity and functional connectivity associated with cognitive impairment in patients with hypertension: a resting-state functional magnetic resonance imaging study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Brain effective connectivity and functional connectivity as markers of lifespan vascular exposures in middle-aged adults: The Bogalusa Heart Study.Frontiers in aging neuroscience · 2023Article
- Brain morphological variability between whites and African Americans: the importance of racial identity in brain imaging research.Frontiers in integrative neuroscience · 2023Article
- Blood pressure-related differences in brain health between young African Americans and Caucasian Americans.Physiological reports · 2021Article
- Disrupted interactions among the hippocampal, dorsal attention, and central-executive networks in amnestic mild cognitive impairment.Human brain mapping · 2018Article
- Interactions of the Salience Network and Its Subsystems with the Default-Mode and the Central-Executive Networks in Normal Aging and Mild Cognitive Impairment.Brain connectivity · 2017Article
- Interactions of Insula Subdivisions-Based Networks with Default-Mode and Central-Executive Networks in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Internal Lipid Profile and Body Lipid Profile in Relation to Cognition: A Cross-Sectional Study in Southern China.American journal of Alzheimer's disease and other dementiasArticle
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Authors and funding
4 authors.
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Abstract
Hypertensive African-Americans have a greater risk of cognitive impairment than hypertensive Caucasian-Americans. The neural basis of this increased risk is yet unknown. Neuroimaging investigations suggest that the normal neural activity comprises complex interactions between brain networks. Recent studies consistently demonstrate that the insula, part of the salience network, provides modulation effects (information flow) over the default-mode and central-executive networks in cognitively normal subjects, and argue that the modulation effect is declined in cognitive impairment. The purpose of this study is to examine the information flow at the nodes of three networks using resting state functional magnetic resonance imaging (MRI) data in cognitively impaired hypertensive individuals with the African-Americans and the Caucasian-Americans races, and to compare the thickness of impaired node between two racial groups. Granger causality methodology was used to calculate information flow between networks using resting state functional MRI data, and FreeSurfer was used to measure cortical thickness from T1-weighted structural images. We found that negative information flow of the insula in both African-Americans and Caucasian-Americans, which was in contrast with previously reported positive information flow in this region of normal individuals. Also, significantly greater negative information flow in insula was found in African-Americans than Caucasian-Americans (Wilcoxon rank sum;
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