Evidence map›Paper›PMID 28620294›Full record

ArticleFrontiers in synaptic neuroscience2017

Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner.

Jessica L Bolton, Steven Marinero, Tania Hassanzadeh, Divya Natesan, Dominic Le, Christine Belliveau, S N Mason, Richard L Auten, Staci D Bilbo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in synaptic neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Prenatal exposure to wildfire-related PMEnvironment international · 2026
    Article
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  7. Article
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  9. Article
  10. Review
  11. Article
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  15. Review
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  17. Article
  18. Neonatal immune stimulation results in sex-specific changes in ultrasonic vocalizations but does not affect seizure susceptibility in neonatal mice.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2024
    Article
  19. Inhaled Pollutants of the Gero-Exposome and Later-Life Health.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
    Review
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jessica L BoltonDepartment of Psychology and Neuroscience, Duke University, DurhamNC, United States.
Steven MarineroDepartment of Neurobiology, Duke University Medical Center, DurhamNC, United States.
Tania HassanzadehDepartment of Psychology and Neuroscience, Duke University, DurhamNC, United States.
Divya NatesanDepartment of Psychology and Neuroscience, Duke University, DurhamNC, United States.
Dominic LeDepartment of Psychology and Neuroscience, Duke University, DurhamNC, United States.
Christine BelliveauDepartment of Psychology and Neuroscience, Duke University, DurhamNC, United States.
S N MasonDepartment of Pediatrics, Division of Neonatal Medicine, Duke University Medical Center, DurhamNC, United States.
Richard L AutenDepartment of Pediatrics, Division of Neonatal Medicine, Duke University Medical Center, DurhamNC, United States.
Staci D BilboDepartment of Psychology and Neuroscience, Duke University, DurhamNC, United States.
Duke University · USDuke Medical Center · USCenter for Autism and Related Disorders · US

Funding

Environmental Toxins and Microglia-Synapse Interactions in AutismR01ES025549 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI BILBO, STACI D, DZIRASA, KAFUI · 2016 to 2020
$2.1M
Sex Differences in Developing Microglia: Implications for Synaptic PruningR01MH101183 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BILBO, STACI D · 2013 to 2017
$2.0M
6 · The paper itself

Abstract

Microglia are the resident immune cells of the brain, important for normal neural development in addition to host defense in response to inflammatory stimuli. Air pollution is one of the most pervasive and harmful environmental toxicants in the modern world, and several large scale epidemiological studies have recently linked prenatal air pollution exposure with an increased risk of neurodevelopmental disorders such as autism spectrum disorder (ASD). Diesel exhaust particles (DEP) are a primary toxic component of air pollution, and markedly activate microglia

Indexed as

air pollutionbrain developmentcortical volumemicrogliamicroglia-neuron interactions

Identifiers

PMID28620294
PMCPMC5449437
OpenAlexW2618453778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.