Evidence map›Paper›PMID 28620241›Full record

ArticleScientific reports2017

TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.

Josiane Lilian Dos Santos Schiavinato, Rodrigo Haddad, Felipe Saldanha-Araujo, João Baiochi, Amélia Goes Araujo, Priscila Santos Scheucher, Dimas Tadeu Covas, Marco Antonio Zago, Rodrigo Alexandre Panepucci

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  18. Intestinal microbiota: a new force in cancer immunotherapy.Cell communication and signaling : CCS · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Josiane Lilian Dos Santos SchiavinatoDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Rodrigo HaddadRibeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Felipe Saldanha-AraujoRibeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
João BaiochiRibeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Amélia Goes AraujoRibeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Priscila Santos ScheucherRibeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.
Dimas Tadeu CovasNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil.
Marco Antonio ZagoNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil.
Rodrigo Alexandre PanepucciNational Institute of Science and Technology in Stem Cell and for Cell Therapy (INCTC) Center for Cell Therapy (CTC) and Regional Blood Center, Ribeirão Preto, SP, Brazil. rapane@gmail.com.ORCID 0000-0002-1119-4352
Universidade de São Paulo · BRUniversidade de Brasília · BRCell Technology (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T cells (Tregs) are essential regulators of immune tolerance. atRA and TGF-β can inhibit the polarization of naïve T cells into inflammatory Th17 cells, favoring the generation of stable iTregs, however the regulatory mechanisms involved are not fully understood. In this context, the roles of individual microRNAs in Tregs are largely unexplored. Naïve T cells were immunomagnetically isolated from umbilical cord blood and activated with anti-human CD2/CD3/CD28 beads in the presence of IL-2 alone (CD4

Indexed as

BiomarkersCell DifferentiationCytokinesFetal BloodGene Expression ProfilingHumansImmunomagnetic SeparationImmunophenotypingMicroRNAsRNA InterferenceTh17 CellsT-Lymphocytes, RegulatoryTranscription, GeneticTranscriptomeTransforming Growth Factor betaBiomarkersCytokinesMicroRNAsTransforming Growth Factor beta

Identifiers

PMID28620241
PMCPMC5472579
OpenAlexW2621975546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.