ArticleScientific reports2017
Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Structural Behavior Analysis of a Bone-Scaffold System According to the Elastic Modulus of Bone Cement and Pore Size in the Proximal Femur.Journal of functional biomaterials · 2026Article
- Biomaterial-based strategies for bone cement: modulating the bone microenvironment and promoting regeneration.Journal of nanobiotechnology · 2025Review
- Current and Future Perspectives of Bioactive Glasses as Injectable Material.Nanomaterials (Basel, Switzerland) · 2024Review
- An Outline on the Advancements in Surgical Management of Osteoporosis-Associated Fractures.Cureus · 2024Review
- Regulation of the antibiotic elution profile from tricalcium phosphate bone cement by addition of bioactive glass.Scientific reports · 2024Article
- Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers.ACS materials Au · 2023Article
- Injection of a PMMA-doped MSC spheroid gel for the treatment of painful osteoporotic vertebral compression fractures.Bioengineering & translational medicine · 2023Article
- Influence of Lithium- and Zinc-Containing Bioactive Glasses on Pulpal Regeneration.European journal of dentistry · 2023Article
- Effect of a bioactive glass-based root canal sealer on root fracture resistance ability.Journal of dental sciences · 2023Article
- The additive effects of bioactive glasses and photobiomodulation on enhancing bone regeneration.Regenerative biomaterials · 2023Article
- An injectable pH neutral bioactive glass-based bone cement with suitable bone regeneration ability.Journal of orthopaedic translation · 2022Article
- Laser Sintering Approaches for Bone Tissue Engineering.Polymers · 2022Review
- A novel bioactive glass-based root canal sealer in endodontics.Journal of dental sciences · 2022Article
- Review
- Cement augmentation for trochanteric fracture in elderly: A systematic review.Journal of clinical orthopaedics and trauma · 2021Review
- [Effects of bioactive glass on proliferation, differentiation and angiogenesis of human umbilical vein endothelial cells].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement.International journal of molecular sciences · 2020Article
- Scaffolds and coatings for bone regeneration.Journal of materials science. Materials in medicine · 2020Review
- Healing potentials of polymethylmethacrylate bone cement combined with platelet gel in the critical-sized radial bone defect of rats.PloS one · 2018Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, more and more attention has been paid to the development of a new generation of injectable bone cements that are bioactive, biodegradable and are able to have appropriate mechanical properties for treatment of vertebral compression fractures (VCFs). In this study, a novel PSC/CS composite cement with high content of PSC (a phytic acid-derived bioactive glass) was prepared and evaluated in both vitro and vivo. The PSC/CS cement showed excellent injectability, good resistance to disintegration, radiopacity and suitable mechanical properties. The in vitro test showed that the cement was bioactive, biocompatible and could maintain its shape sustainably, which made it possible to provide a long-term mechanical support for bone regeneration. Radiography, microcomputed tomography and histology of critical sized rabbit femoral condyle defects implanted with the cements proved the resorption and osteoinductivity of the cement. Compared with the PMMA and CSPC, there were more osteocyte and trabeculae at the Bone-Cement interface in the group PSC/CS cement. The volume of the residual bone cement suggested that PSC/CS had certain ability of degradation and the resorption rate was much lower than that of the CSPC cement. Together, the results indicated that the cement was a promising bone cement to treat the VCFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.