Evidence map›Paper›PMID 28620227›Full record

ArticleScientific reports2017

Gene-physical activity interactions in lower extremity performance: inflammatory genes CRP, TNF-α, and LTA in community-dwelling elders.

Chiu-Shong Liu, Tsai-Chung Li, Chia-Ing Li, Li-Na Liao, Chuan-Wei Yang, Chih-Hsueh Lin, Nai-Hsin Meng, Wen-Yuan Lin, Sung-Lin Hu, Jen-Hao Hsiao and 2 more

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In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Chiu-Shong LiuSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Tsai-Chung LiDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.ORCID 0000-0002-3346-7462
Chia-Ing LiSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Li-Na LiaoSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Chuan-Wei YangDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Chih-Hsueh LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Nai-Hsin MengSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Wen-Yuan LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.ORCID 0000-0002-5220-5759
Sung-Lin HuDepartment of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Jen-Hao HsiaoBioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan.
Fang-Yang WuDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Cheng-Chieh LinSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. cclin@mail.cmuh.org.tw.
China Medical University · TWAsia University · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed gene-gene and gene-physical activity interactions of polymorphisms in C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and lymphotoxin α (LTA) genes on lower extremity performance in community-dwelling elders in Taiwan. Five SNPs (rs1205, rs1130864, rs1800947, rs2794520, and rs3093059) of CRP gene, three SNPs (rs909253, rs1041981, and rs2239704) of LTA gene, and three SNPs (rs3093662, rs1800629, and rs1799964) of TNF-α gene of 472 unrelated elders were genotyped. Lower extremity performance included timed up-and-go test (TUG), walking speed, weight-adjusted leg press (waLP), and timed chair stand (TCS). We detected significant interactions between physical activity with CRP rs2794520, rs1205, and rs3093059; LTA rs909253 and rs1041981; and TNF-α rs1799964 for TCS in women after covariate adjustment (all P < 0.05). In men, significant interactions between physical activity with CRP rs2794520, rs1205, and rs3093059; and LTA rs909253 and rs1041981 for TUG; with CRP rs2794520, rs1205, rs1130864, and rs3093059; and LTA rs909253 and rs1041981 for walking speed; and with TNF-α rs3093662 for waLP after covariate adjustment (all P < 0.05). These variants also significantly interacted with physical activity on TCS in women and on walking speed in men. These results show inflammatory genes are involved in lower extremity performance, likely via gene-physical activity interactions.

Indexed as

ExercisePolymorphism, Single NucleotideC-Reactive ProteinGenotypeHumansIndependent LivingLocomotionLower ExtremityLymphotoxin-alphaTaiwanTumor Necrosis Factor-alphaC-Reactive ProteinLTA protein, humanLymphotoxin-alphaTumor Necrosis Factor-alpha

Identifiers

PMID28620227
PMCPMC5472589
OpenAlexW2622312804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.