ArticleScientific reports2017
Transcriptomic Analysis of the Regulation of Lipid Fraction Migration and Fatty Acid Biosynthesis in Schizochytrium sp.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 48 citations in OpenAlex.
- Study on the regulatory effects of Δ4-DES and LACS genes on the synthesis of LC-PUFAs, based on the transcriptome changes induced by fluridone in Aurantiochytrium limacinum OUC86.World journal of microbiology & biotechnology · 2025Article
- The Metabolism of Reactive Oxygen Species and Their Effects on Lipid Biosynthesis of Microalgae.International journal of molecular sciences · 2023Review
- Nitrogen Starvation Enhances the Production of Saturated and Unsaturated Fatty Acids inMarine drugs · 2022Article
- Deciphering and engineering the polyunsaturated fatty acid synthase pathway from eukaryotic microorganisms.Frontiers in bioengineering and biotechnology · 2022Review
- Transcriptome characterization of Larrea tridentata and identification of genes associated with phenylpropanoid metabolic pathways.PloS one · 2022Article
- Transcriptome analysis of malate-inducedFrontiers in microbiology · 2022Article
- Glyap1 regulates pneumocandin BApplied microbiology and biotechnology · 2021Article
- Genome and Transcriptome Analyses Provide Insight Into the Omega-3 Long-Chain Polyunsaturated Fatty Acids Biosynthesis ofFrontiers in microbiology · 2020Article
- Comparative Transcriptomics Analysis of the Responses of the Filamentous FungusFrontiers in microbiology · 2020Article
- Lipid and DHA-production in Aurantiochytrium sp. - Responses to nitrogen starvation and oxygen limitation revealed by analyses of production kinetics and global transcriptomes.Scientific reports · 2019Article
- Screening chemical modulators of benzoic acid derivatives to improve lipid accumulation inBiotechnology for biofuels · 2019Article
- Development of a cooperative two-factor adaptive-evolution method to enhance lipid production and prevent lipid peroxidation inBiotechnology for biofuels · 2018Article
- Transcriptome and gene expression analysis of docosahexaenoic acid producerBiotechnology for biofuels · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizochytrium sp. is the main source of docosahexaenoic acid-rich oil, which is widely used in food additive and pharmaceutical industry. In this study, using RNA-seq, comparative transcriptomic analyses were performed at four stages of DHA fermentation by Schizochytrium sp to get potential genes related to cell transition from cell growth to lipid accumulation and then to lipid turnover. 1406, 385, 1384 differently expressed genes were identified by comparisons in pairs of S2 vs S1, S3 vs S2 and S4 vs S3. Functional analysis revealed that binding and single-organism process might be involve in the cell transition from cell growth to lipid accumulation while oxidation-reduction process played an important role in the transition from lipid accumulation to lipid turnover. pfaC in the PKS pathway showed higher sensitivity to the environmental change, which might be the key regulator for enhancing PUFA biosynthesis in the future. Some other genes in signal transduction and cell transport were revealed to be related to lipid turnover, which would enrich the current knowledge regarding lipid metabolism and help to enhance the DHA production and enrich different lipid fractions by Schizochytrium in the future.
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